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muscarinic agonist/antagonist
muscarinic agonist/antagonist
8
Pharmacology
Professional
11/01/2011

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Term
*Bethanechol
Definition
Muscarinic agonist, orally
-selective for M3 in GI and bladder
*stimulate intestine and bladder
*ex. urinary retention (will promote micturition)
Contraindicated:
-asthmatic
-peptic ulcers
-coronary insufficiency
Term
Pilocarpine
Definition
Muscarinic agonist
-1st choice for open angle glaucoma
Term
Carbachol (Carbamylcholine)
Definition
Muscarinic agonist
-open angle glaucoma
SE: impaired night vision (contracts ciliary muscles of the eye for near vision, miosis)
Term
*Atropine
Definition
nonselective Muscarinic Antagonist
*use: cholinesterase poisoning (life saving short term because it blocks muscarinic effects)
-crosses BBB poorly

in general
-overactive bladder
-anti-parinsonian treatment
Term
Scopolamine
Definition
Muscarinic Antagonist
-methylated atropine
*Use: anesthetic adjuvant, motion sickness
-potent muscarinic antagonist with INCREASED CNS activity
Term
Pirenzepine
Definition
Muscarinic Antagonist
-spec. for M1 subtype--> ULCERS
Term
Ipratropium
Definition
Muscarinic Antagonist
-bronchodilation
Term
Tiotropium
Definition
Muscarinic Antagonist
-bronchodilation
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