Shared Flashcard Set

Details

Multiple Myeloma
MS Module
21
Medical
Graduate
05/12/2009

Additional Medical Flashcards

 


 

Cards

Term
What do you need for diagnosis of multiple myeloma with regards to major and minor criteria?  (2 possibilities)
Definition

1 major, 1 minor

 

 

3 minor

Term
What ethnic group is multiple myeloma low in and which is it high in?
Definition

low in Asians

high in African Americans

Term
What is the second most common blood maglignacy?
Definition
multiple myeloma (obviously)
Term

What is the peak age of onset for multiple myeloma?

 

What is happening to this age of onset?

Definition

60-70

 

 

the age of onset is decreasing

Term
What chromosome carries the most common cytogenetic abnormality for multiple myeloma?
Definition
13q
Term
What two chromosomes are most linked to multiple myeloma?
Definition
13 and 14
Term
How is the diagnosis of multiple myeloma usually made (what test)?
Definition
biopsy
Term
How many cells in the biopsy must be myeloma plasma cells to even begin to think multiple myeloma in the differential?
Definition
>10%
Term
What is the name given to plasma cells in multiple myeloma, when filled with inclusions?
Definition
mott cells
Term
What are the two types of inclusions found in plasma cells in multiple myeloma and where in the cell are they found?
Definition

Russell bodies in cytoplasma

Dutcher in nucleus

Term
WHat marker is found in plasma cells of multiple myeloma?
Definition

CD 38

 

NOT CD 19/20

Term
How does the prognosis of plasma cell leukemia compare to the prognosis of multiple myeloma?
Definition
it is worse
Term
How does the prognosis of plasmacytoma compare to the prognosis of multiple myeloma?
Definition
it is better
Term
What is true of the rim of the punched out lesions on XRAY of multiple myeloma?
Definition
non sclerotic rim
Term
What does POEMS stand for?
Definition

demyelinationg polyneuropathy

organomegally

endocrinopathy

serum M spike

skin lesions

Term
Will light chains be detected in the urine of a standard dip stick urine exam?
Definition
no
Term
What type of amyloidosis is present in mutliple myeloma?
Definition
AL (primary amyloidosis)
Term
What is the median survival of multiple myeloma patients?
Definition
3 years
Term
What is the typical treatment for solitary lesions in multiple myeloma?
Definition
radiation
Term

What is a common chemo drug used in treatment of multiple myeloma?

 

Why is it a good treatment?

Definition

melphalan

 

can be given orally

Term
What are three general treatments for multiple myeloma depending on the stage?
Definition

radiation

chemotherapy

stem cell transplant

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