-Autosomal recessive

-skeletal abnormalities and mental retardation -dwarfism, corneal clouding, hepatosplenomegaly, valvular heart disease

-accumulate heparan sulfate and dermatan sulfate -complete deficiency in α-L-Iduronidase

-death occurs usually by age 10

-X-linked

-skeletal abnormalities and mental retardation

-accumulate heparan sulfate and dermatan sulfate

-complete deficiency in Iduronidase sufatase

-death occurs usually by age 10

-Autosomal recessive

-accumulation of heparan sulfate

-minor physical effects, but severe mental retardation

-deficiency in heparan-N-sulfatase

-Autosomal recessive

-accumulation of heparan sulfate

-minor physical effects, but severe mental retardation

-deficiency in α-N-acetyl-glucosaminidase

-Autosomal recessive

-accumulation of heparan sulfate

-minor physical effects, but severe mental retardation

-deficiency in acetyl-CoA, α-glucosaminide acyltransferase

-Autosomal recessive

-accumulation of heparan sulfate

-minor physical effects, but severe mental retardation

-deficiency in N-acetylglucosamine 6-sulfatase