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MSK-Kuehn
I
17
Medical
Professional
05/29/2010

Additional Medical Flashcards

 


 

Cards

Term
The --- induces differentiation of somites, which further differentiate into ----, ---- and ----.
Definition
The notochor induces differentiation of somites which further differentiate into myotome, dermatome and sclerotome
Term

What does the lateral plate differentiate into and what are these structures associated with?

 

Definition

The lateral plate differentiates into

splanchnopleure -- associated with internal organs

and

somatopleure -- associated with body wall.

Term
What is the intermediate mesoderm reffered to as (what does it generate)?
Definition
Nephrogenic (makes the kidneys and most of the reproductive organs)
Term
When do we get early differentiation of somites?
Definition
4th wk
Term
what structures does the neural crest contribute to in the head?
Definition
Neural crest in the body gives rise to peripheral nn system elements, but in the head it also contributes to connective tissue elements - flat bones of skull and cartilage.
Term
what structure do the mm of the body come from and when do they migrate to their final location?
Definition
All mm of the body come from dermomyotome (originally somite), and the migrate to their final location begining of the 5th wk.
Term
where do the vertabrae and intervertebral discs come from?
Definition
They come from the sclerotome part of the somites
Term
where does the body skeleton come from (other than the vertebrae)?
Definition
The Somatopleure, which is part of the lateral plate mesoderm.
Term
This initiates differentiation in tissues under BMP influence.
Definition
FGF-10
Term
The outer edge of the limb bud expresses this gene.
Definition
AER
Term
What do WNT and BMP4 do to somites?
Definition
Their dorsal influence differentiates somites into deromomyotome.
Term
What is the influence of shh on sclerotome?
Definition
SHH from notochord has a ventral influence that differentiates the sclerotome.
Term
What do epaxial mm make, what are they innervated by?
Definition
They originate from dermomyotome and make up the deep back mm, which are innervated by the dorsal rami of spinal nn.
Term
What do hypaxial mm make, what is their innervation?
Definition

Hypaxial mm originate from dermamyotome, migrate outside of the blastimal skeleton from somatopleure and make appendicular and body wall mm. they are innervated by ventral rami of spinal nn.

 

WNT, SHH, and BMP are the major influence.

Term
What influences do SHH and Retinoic acid have on developement?
Definition
Ant/Post relatoiships
Term
What are HOX genes involved in?
Definition
HOX genes regulate bone type and shape.
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