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Motility Midterm
Abnormalities of Fixation
30
Medical
Professional
09/24/2008

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Term
Saccades
Definition
represent the fastest eye movement in humans and primates which allow rapid refixation of objects. They exist because of fovea
Term
Abnormalities of fixation
Definition
slow drift, saccadic intrusions, nystagmus
Term
Slow drifts
Definition
are irregular and slow fixation eye movement patterns typical found in functional amblyopia and has been observed in patients with macular scotomas
Term
How do slow drift affect vision
Definition
they cause the retinal image of a stationary target to impinge upon different retinal loci
Term
In patients with macular scotoma the velocity of drift tends
Definition
to increase as eccentric retinal locus increased. The condition may be assessed in visuoscopy.
Term
Saccadic Intrusions
Definition
These represent abnormally large fixation saccades which can be seen as darting to-and-fro under the visuoscope and tend to occur when an attempt is made to fixate (foveate) a stationary target.
Term
Square Wave Jerks
Definition
Typically seen in patients with functional strabismus. They are sporadic in occurrence and are present in light and dark conditions as “back-to-back” oscillations with a 200 msec latency. They have a range of amplitude of (0.5-3 deg)
Term
Clinical Significance in Square Wave Jerks
Definition
1. They are observed in normals 25-60%, but can be transiently suppressed in normals by the HOLD and FIXATE command. 2. When the saccades are consistently present with increasing frequency (>>30 per min), they may be diagnostic of: a. cerebellar disease b. early manifestation of a congenital nystagmus.
Term
Possible etiology for Square wave jerks of the abnormally large square wave jerks includes:
Definition
disorder of the Pause cells, cerebellar-related saccadic gain control (dysmetria)
Term
In the absence of an underlying disease condition, square wave jerks can be
Definition
suppressed
Term
Square-wave Jerks
Definition
These are very larger [5-15 deg] saccades, They occur more frequently (at 2-3 Hz), Latency of 50-150 msec and remove the eye from the target for only about 100 ms.
Term
Macro Square-wave Jerks are primarily found in
Definition
cerebellar disease such as multiple sclerosis.
Term
Macro-saccadic Oscillations are different from macro square-wave jerks because:
Definition
1. They produce a sequence of increasing and decreasing amplitude saccades on either sides of the fixation point. 2. They have inter-saccadic intervals of 200 msec.
Term
Macro-saccadic Oscillations represents the
Definition
classic case of an unstable high gain system oscillation.
Term
Nystagmus
Definition
These are rhythmic involuntary oscillations of the eye.
Term
Nystagmus Prevalence:
Definition
50 % of patients with strabismus have nystagmus but only 15% of patients with congenital nystagmus have strabismus. It exists in either a pendulum or a jerk form. In the pendulum type foveation occurs at the peak of the waveform during which velocity is slowest. In the jerk type foveation occurs immediately after the rapid corrective saccade for ~100 msec
Term
Nystagmus characteristics
Definition
1. Null Position of a nystagmus , This identifies the direction of gaze for which the intensity of the nystagmus is least with head in the straight-ahead position. 2. V.A. is optimal. 3. Patients with nystagmus tilt their heads in direction opposite to the null position.
Term
Pendular Nystagmus
Definition
This is due to a high-gain instability in the slow control system and may be diagnostic of: 1. congenital (albinism) or acquired (demyelinating diseases; brainstem lesions and amblyopia).A congenital form is typically purely horizontal
Term
Pendular Nystagmus acquired form (components, amplitude, frequency, peak velocity
Definition
usually has vertical and torsional components and exhibit more inter-ocular waveforms variability. amplitude: 0.5-10 deg; typically 2-8 deg. frequency: 2-8 Hz peak velocity: ~100 deg/sec
Term
Pendular Nystagmus Treatment:
Definition
auditory biofeedback therapy
Term
Jerk Nystagmus
Definition
Congenital jerk form: 1. seen during the first year of life 2. amplitude: 0.25-5 deg 3. frequency: 1-2 Hz 4. has an exponentially increasing slow phase velocities as high as 100 deg/sec 5. the slow phase moves the eye away from the object.
Term
Jerk Nystagmus
Definition
It is horizontal and conjugate, corrective saccades return the eye to target for an extended foveation period of (50-100 msec) or more. Nystagmus intensity decreases in binocular near viewing. The direction of nystagmus is defined by the direction of the saccadic (fast) component
Term
Acquired Jerk Nystagmus (Gaze Evoked Nystagmus) Characteristics:
Definition
Similar in character to the congenital form. Has a slow phase velocity waveform that decreases exponentially. The slow phase moves the eye away from the eccentric position of gaze towards the midline.
Term
Acquired Jerk Nystagmus (Gaze Evoked Nystagmus) The physiological form (amplitude, frequency, and occurs when gaze angle is?
Definition
an amplitude of 1-2 deg., frequency of 1-3 Hz, occurs when gaze angle is 25-65 deg
Term
In manifest latent nystagmus, the direction is towards the
Definition
viewing eye. This condition reflects a leaky neural integrator with an exponential decay function.
Term
Nystagmus (Foveation Strategy)
Definition
Foveation of target occurs at positions 0 & 2 (Fig. 10) where eye velocity is slowest. In the pendulum form it corresponds to the peak of waveform. In the jerk form it is immediately after the saccade.
Term
Nystagmus types Congenital
Definition
Latent or Manifest Latent, Binocular, Horizontal, Jerk or pendulum, Diminished by convergence, Increased by attempted fixation, Inverted OKN, Torticollis , Abolished in sleep
Term
Nystagmus types Acquired
Definition
Opsoclonus or Ocular flutter, Oscillopsia
Term
The direction of nystagmus is defined
Definition
by the direction of the saccadic (fast) component
Term
Nystagmus intensity
Definition
decreases in binocular near viewing
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