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Molecular Biology 1
Test 1
17
Microbiology
Undergraduate 3
02/17/2011

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Term
Adenine
Definition
A purine base, C5H5N5, that is the constituent involved in base pairing with thymine in DNA and with uracil in RNA.
Term
Antiparallel
Definition
The opposite orientation of the two complementary strands or deoxyribonucleic acid, 5′ to 3′ and 3′ to 5′.
Term
Central Dogma
Definition
1. The DNA replicates its information in a process that involves many enzymes: replication.
2. The DNA codes for the production of messenger RNA (mRNA) during transcription.
3. In eukaryotic cells, the mRNA is processed (essentially by splicing) and migrates from the nucleus to the cytoplasm.
4. Messenger RNA carries coded information to ribosomes. The ribosomes "read" this information and use it for protein synthesis. This process is called translation.
Term
Chargaff's Rules
Definition
The first rule holds that a double-stranded DNA molecule globally has percentage base pair equality: %A = %T and %G = %C.[6] The rigorous validation of the rule constitutes the basis of Watson-Crick pairs in the DNA double helix.
The second rule holds that both %A ~ %T and %G ~ %C are valid for each of the two DNA strands.[7] This describes only a global feature of the base composition in a single DNA strand.[8]
Term
Cytosine
Definition
A pyrimidine base, C4H5N3O, that is the constituent of DNA and RNA involved in base pairing with guanine.
Term
Guanine
Definition
A purine base, C5H5ON5, that is an essential constituent of both RNA and DNA.
Term
Thymine
Definition
A pyrimidine base, C5H6N2O2, that is an essential constituent of DNA.
Term
Uracil
Definition
A pyrimidine base, C4H4N2O2, that is an essential constituent of RNA.
Term
Mendel
Definition
3 laws of inheritance
Term
Law of Segregation
Definition
when any individual produces gametes, the copies of a gene separate so that each gamete receives only one copy. A gamete will receive one allele or the other.
Term
Law of Independent Assortment
Definition
alleles of different genes assort independently of one another during gamete formation.
Term
Miescher
Definition
Identified DNA as the carrier of inheritance
Term
Garrod
Definition
Studied alkaptonuria.
First published account of recessive inheritance in humans
Term
Beadle & Tatum
Definition
1941.
Made one gene/one enzyme hypothesis.
Deduced role of genes in regulating biochemical events within cells.
Term
One Gene/One Enzyme Hypothesis
Definition
idea that genes act through the production of enzymes, with each gene responsible for producing a single enzyme that in turn affects a single step in a metabolic pathway.
Term
Griffith's Experiment
Definition
Rough/Smooth/Heat-killed smooth/Rough & Heat-killed smooth strains in rats.
Transferring of genetic information via transformation factor.
Term
Avery, MacLeod, McCarty Experiment
Definition
DNA is what causes bacterial transformation.
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