Term
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Definition
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Term
| What are their relation to MO? |
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Definition
- Exotoxins - release/secreate from cell of MO
- Endotoxins - part of the cell wall structure of the MO (Lipid A)
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Term
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Definition
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Term
| What is their heat stability? |
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Definition
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Term
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Definition
- Exotoxins - highly toxic in small amounts i.e. Clostridium sp.
- Endotoxins - weakly toxic, high doses required
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Term
| What are their effects on the host? |
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Definition
- Exotoxins - specific to toxin type (i.e. neurotoxins, cytotoxins, enterotoxins)
- Endotoxins - fever, endotoxin shock (large dose in bloodstream can cause death)
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Term
| What is their antigenic ability? |
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Definition
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Term
| What are their abilities to convert to toxoids? |
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Definition
- Exotoxins - can be converted to toxoid
- Endotoxins - no, unable to convert to toxoid
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Term
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Definition
| An MO with exotoxins that stimulate the immune system(IS) to produce corresponding (specific) antibodies (Ab) that will react with the MO and destroy it. |
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Term
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Definition
- An exotoxins (which is toxic and antigenic) is treated / modified in a lab to make it nontoxic and antigenic).
- Used in the creation of immunization vaccines i.e. tentenus diphtheria acellular pertussis (DTaP - for whooping cough)
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