Term
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Definition
| docking protein; envelope protein, attachment to host T cell |
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Term
|
Definition
| transmembrane, envelope protein; fusion and entry |
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Term
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Definition
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Term
|
Definition
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Term
|
Definition
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Term
|
Definition
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|
Term
| HIV virus binds ___ or ___ on T cells |
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Definition
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|
Term
| HIV binds ___ on macropages |
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Definition
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Term
|
Definition
| ELISA (highly sensitive) and confirmed with western blot (highly specific) |
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Term
|
Definition
| monitory effect of drug therapy, newborns |
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Term
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Definition
| CD4 < 200 with aids defining illness |
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Term
|
Definition
| wide dissemination of virus, seeding of lymphoid organs, first couple months |
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Term
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Definition
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|
Term
| 4 stages of HIV infection |
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Definition
| Fluelike (acute), feeling fine (latent), falling count, final crisis |
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Term
| HIV with fever, cough and hepatosplenomegaly |
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Definition
| histoplasma capsulatum; CD4 <100 |
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Term
| HIV with fluffy cottage-cheese lesions, pseudohyphae |
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Definition
| Candida; CDF < 400 esophageal if <100 |
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Term
| HIV with superficial vascular proliferation; biopsy reveals neutrophilic inflammation |
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Definition
| bartonella henselae (bacillary angiomatosis) |
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Term
| HIV with CD4 <200 with chronic, watery diarrhea |
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Definition
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Term
|
Definition
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|
Term
| HIV with ring enhancing brain abscess |
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Definition
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Term
|
Definition
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|
Term
| HIV with retinitis and cotton wool spots |
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Definition
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|
Term
| HIV with retinitis and cotton wool spots |
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Definition
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|
Term
| HIV with neoplastic proliferation of vasculature |
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Definition
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|
Term
| HIV with hairy leuoplakia |
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Definition
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|
Term
| HIV with non-hodgkin lymphoma |
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Definition
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|
Term
| HIV with squamous cell carcinoma of anus or cervix |
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Definition
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|
Term
| HIV with primary CNS lymphoma |
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Definition
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|
Term
| HIV with interstitial pneumonia |
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Definition
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|
Term
| HIV with pleuritic pain, hemptysis, infiltrates |
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Definition
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|
Term
| HIV with CD4 < 200 and pneumonia |
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Definition
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|
Term
| HIV with TB like disease with CD4 < 50 |
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Definition
|
|
Term
| Hepatitis: RNA picornavirus |
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Definition
|
|
Term
|
Definition
|
|
Term
| Hepatitis: short incubation |
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Definition
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|
Term
|
Definition
|
|
Term
| Hepatitis: usually asymptomatic or acute |
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Definition
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Term
|
Definition
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Term
|
Definition
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Term
|
Definition
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|
Term
| Hepatitis: maternal-fetal |
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Definition
|
|
Term
| Hepatitis: long incubation |
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Definition
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|
Term
|
Definition
| HBV (acts as oncogene) and HCV (chronic inflammtion) |
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|
Term
| Hepatitis: RNA flavivirus |
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Definition
|
|
Term
| Hepatitis: blood transmission |
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Definition
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|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| Hepatitis: no carrier state |
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Definition
|
|
Term
| Hepatitis: depends on HbsAg |
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Definition
|
|
Term
| Hepatitis: RNA delta virus |
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Definition
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|
Term
|
Definition
|
|
Term
| Hepatitis: high mortality in pregnancy |
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Definition
|
|
Term
| HBV: signifies active disease |
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Definition
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|
Term
|
Definition
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|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| HBV: high transmissibility |
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Definition
|
|
Term
| HBsAg +, HBeAg +, anti-HBcAb IgM + |
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Definition
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|
Term
|
Definition
|
|
Term
| HBsAg +, HBeAg +, anti-HBcAb IgG + |
|
Definition
| chronic HBV with high infectivity |
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Term
| HBsAG +, anti-HBeAb +, anti-HBcAb + |
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Definition
| chronic HBV, low infectivity |
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Term
| anti-HBsAb, anti-HBeAb +, anti-HBcAb + |
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Definition
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|
Term
|
Definition
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Term
|
Definition
| exchange of genes between 2 chromosomes by crossing over within regions of significant base sequence homology |
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Term
|
Definition
| viruses with segmented genres exchange segments; causes influenza pandemics |
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Term
|
Definition
| when 1 of 2 viruses that infect the cell has a mutation that results in a nonfunctional protein; the non mutated virus complements the mutated one by making a functional protein that serves both viruses |
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Term
|
Definition
| with simultaneous infection with 2 viruses; |
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|
Term
live attenuated vaccines
- immunity ilicited
- examples |
|
Definition
- humoral and cell mediated
- smallpox, yellow fever, chicken pox, sabin's polio, MMR |
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|
Term
killed vaccines
- immunity ilicited
- examples |
|
Definition
- humoral only
- rabies, influenxa, salk poilio and HAV |
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|
Term
| recombinant vacines examples |
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Definition
|
|
Term
DNA viral genomes:
- ds or ss?
- linear or circular? |
|
Definition
- all ds except parvovirus B19
- all linear except papilloma, polyoma and hepadna |
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|
Term
RNA viral genomes:
- ss or ds?
- positive sense examples |
|
Definition
- all ss except reoviridae
- retro, toga, flavi, corona, hepe, calici and picorna |
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|
Term
| naked viral genome infectivity |
|
Definition
| require enzymes contained in the complete vision for infectivity |
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Term
| are viruses diploid or haploid? |
|
Definition
| all haploid except retroviruses |
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|
Term
viral replication:
- DNA
- RNA |
|
Definition
- all in nucleus except poxvirus
- all in cytoplasm except influenza and retroviruses |
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Term
|
Definition
| calici, picorna, reo, parvo, adeno, papilloma and polyoma |
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|
Term
| where does the herpes envelope come from? |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| HHHAPPPPy = hepadna, herpes, adeno, pox, polyoma, papilloma, parvovirus |
|
|
Term
|
Definition
| HSV1, HSV2, HHV3 = VZV; HHV4= EBV, HHV5 = CMV, HHV6 = roseola, HHV7 =insignificant, HHV8 = kaposi |
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|
Term
|
Definition
|
|
Term
|
Definition
| febrile pharyngitis, acute hemorrhagic cystitis, pneumonia, conjunctivitis |
|
|
Term
|
Definition
| aplastic crises; slapped cheeks in children; RA like symptoms in adults |
|
|
Term
HPV
- wart subtypes
- cervical cancer subtypes |
|
Definition
- 1, 2, 6 and 11
- 16, and 18 |
|
|
Term
|
Definition
JC virus= PML
BK virus= transplant patients in kidney |
|
|
Term
|
Definition
| smallpox, vaccinia (cowpox), and molluscum contagious |
|
|
Term
| flesh colored dome lesions with central dimple |
|
Definition
|
|
Term
| temporal lobe encephlitis |
|
Definition
|
|
Term
latent in:
- trigeminal ganglia
- sacral tanglia
- dorsal root ganglia |
|
Definition
|
|
Term
| spread by respiratory secretions |
|
Definition
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|
Term
|
Definition
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|
Term
|
Definition
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|
Term
| retinitis in AIDS patients |
|
Definition
|
|
Term
| high fevers for several days then diffuse macular rash |
|
Definition
|
|
Term
|
Definition
| smear of vesicle shows multinucleate giant cells; for HSV1, 2 and VZV |
|
|
Term
|
Definition
|
|
Term
| atypical lymphocytes: B or T cells? |
|
Definition
| T cells that are reactive to the infected B cells |
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|
Term
|
Definition
| detected by agglutination of sheep or horse RBCs in EBV |
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|
Term
|
Definition
| burkitts, hodgkins, nasopharyngeal carcinoma |
|
|
Term
| medically important reoviruses |
|
Definition
| coltivirus and rotavirus; DS! |
|
|
Term
| #1 cause of fatal diarrhea in children |
|
Definition
|
|
Term
| medically important pirocnraviruses |
|
Definition
| polio, echo, rhino, coxsackie and HAV |
|
|
Term
|
Definition
| echovirus, coxsackie, mumps and enterovirus |
|
|
Term
| hand foot and mouth disease |
|
Definition
|
|
Term
| medically important hepevirus |
|
Definition
|
|
Term
| medically important calicivirus |
|
Definition
| Norwalk virus = viral gastroenteritis |
|
|
Term
| medically important flaviviruses |
|
Definition
| HCV, yellow fever, dengue, st louis encephalitis and west nile virus |
|
|
Term
| medically important togaviruses |
|
Definition
| rubella, easter equine encephalitis and western equine encephalitis |
|
|
Term
| medically important retroviruses |
|
Definition
|
|
Term
| medically important paramyxoviruses |
|
Definition
| parainfluenza, RSV, rubella and mumps |
|
|
Term
| medically important filoviruses |
|
Definition
| ebola/marburg hemorrhagic fever |
|
|
Term
| medically important arenaviruses |
|
Definition
| LCMV and lassa fever encephalitis |
|
|
Term
|
Definition
|
|
Term
| medically important bunyaviruses |
|
Definition
| california encphalitis, sandfly/rift valley fevers, crimean-congo hemorrhagic fever, hantavirus |
|
|
Term
| medically important deltavirus |
|
Definition
|
|
Term
|
Definition
| arenavirus, bunyaviruses, paramyxoviruses, orthomyxoviruses, filoviruses and rhabdoviruses |
|
|
Term
|
Definition
| bunyaviruses, orthomyxoviruses, arenaviruses and reoviruses |
|
|
Term
|
Definition
| fecal oral = polio, echo, coxsackie and HAV |
|
|
Term
|
Definition
| common cold >100 serologic types |
|
|
Term
| rhinovirus: acid stable or labile? |
|
Definition
|
|
Term
yellow fever
- transmission
- symptoms |
|
Definition
-Aedes mosquito
- high fever, black vomit and jaundice |
|
|
Term
rotavirus
- epidemiology
- mechanism |
|
Definition
- inter months in day care centers
- vilous destruction with atrophy leads to dec absorption of Na and water |
|
|
Term
influenza virus
- virulence factors
- inc risk of
- vacine |
|
Definition
- hemagglutinin (viral entry) and neuraminidase (virion release)
- bacterial superinfection
- killed with 2A and 1B |
|
|
Term
|
Definition
shift = reassortment of viral genomes
drift= minor changes with random mutation |
|
|
Term
|
Definition
| fever, postauricular adenopathy, LAD, arthralgias, truncal rash that starts at head and moves down |
|
|
Term
| symptoms of parainfluenza |
|
Definition
|
|
Term
|
Definition
| bronchiolitis, pneumonia in infants |
|
|
Term
| virulence of paryamysoviruses |
|
Definition
| surface F protein which causes respiratory epithelial cells to fuse and form multinucleate cells |
|
|
Term
|
Definition
| kplic spots, cough coryza and conjunctivitis; descending maculopapular rash |
|
|
Term
|
Definition
| SSPE, encephalitis and giant cell pneumonia (IS) |
|
|
Term
|
Definition
| parotitis, orchitis and aseptic meningitis; can cause sterility |
|
|
Term
|
Definition
|
|
Term
|
Definition
| fever, malaise -> agitation, photophobia, hydrophobia -> paralysis , coma -> death |
|
|
Term
|
Definition
|
|
Term
|
Definition
| travels to CNS by migrating in a retrograde fashion up nerve axons |
|
|
Term
|
Definition
| PrPc -> PrPsc = transmissible; dementia ataxia and death with spongiform encephalopathy |
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