Term
|
Definition
| Only for 1 infectious agent |
|
|
Term
| What are some characteristics of H1N1? |
|
Definition
-Monovalent
-inactivated
-Allergic response (eggs) Type 1 hypersensitivity |
|
|
Term
| Give an example of trivalent |
|
Definition
|
|
Term
| What disease is a complication with H1N1? |
|
Definition
| Guillian-Barres Syndrome bc of molecular mimicry |
|
|
Term
| What is clonal selection and differentiation? |
|
Definition
| Ability for a single cell to differentiate into many lymphocytes with different specificities of Abs. Then a specific clone/cell becomes monoclonal specific to an Ag |
|
|
Term
| What cells are selected to participate in a specific immune response ? |
|
Definition
| Only the T cells and B cells that can bind to the Ag of the pathogen are selected. |
|
|
Term
| Describe steps of specific immune response |
|
Definition
-Mixture of (polyclonal Abs) T cells and B cells with different Ag specificities moved towards pathogen
-The Ag has 2 epitopes
-Proliferation of cells with receptors capable of binding epitopes of the Ag creates monoclonal Abs with a single specificity |
|
|
Term
| Constant region of Ab defines |
|
Definition
|
|
Term
| VAriable region of Ab defines |
|
Definition
|
|
Term
|
Definition
| T cell receptors (TCR) and Ig |
|
|
Term
| What's the basic structure of Abs? |
|
Definition
-2 Heavy chains 50K (4 domains)
-2 Light chains 25 K (2 domains)
-Disulfide bonds link chains together
|
|
|
Term
| Where are the L chain and H chain of Abs connected? |
|
Definition
| L chains pair with amino terminal portion of H chains and become linked using disulfide bonds |
|
|
Term
| What are the L chain domains? |
|
Definition
|
|
Term
| What are the H chain domains? |
|
Definition
-Mew
-GAmma
-Delta
-Alpha
-Epsolon
|
|
|
Term
|
Definition
| Dependent on class of Ab (IgG, IgA etc.) |
|
|
Term
| What types of enzymes can separate discrete functional regions of IgG? |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| Cleaves bivalent IgG into 2 monovalent Fab fragments and 1 Fc |
|
|
Term
| During papain digestion describe capabilities of Fab and Fc |
|
Definition
-Fab retains Ab binding site
-Fc retains binding sites for C' and Fc receptors on effector cells |
|
|
Term
| What can be done with fragments (pieces) resulting from proteolytic cleavage? |
|
Definition
-Fragments can be used in the lab since they still have binding specificty
-You can modify fragments in lab |
|
|
Term
|
Definition
|
|
Term
| Valent can also refer to... |
|
Definition
|
|
Term
| If Guillian Barre syndrome is present up to 6 weeks prior to H1N1 injection patient may have... |
|
Definition
| reduced immune response to immunization |
|
|
Term
| Describe (GBS) Guillian Barre Syndrome |
|
Definition
-Neurological disorder with peripheral nerve demylination
-Thought to be immunologically mediated
-Damage to myelin or Schwann cells that make myelin
-molecular mimicry |
|
|
Term
| GBS is associated with... |
|
Definition
-Campylobacter (G1 inf)
-SLE
-Hodgkins
-Lyme disease
|
|
|
Term
|
Definition
-vaccinations
-epidural anesthesia
-thrombolytic agents |
|
|
Term
| Primary mode of treatment for GBS |
|
Definition
|
|
Term
|
Definition
-Acute inflammation of myelin
-Acute nerve degeneration
-Main lesions |
|
|
Term
| Changes in GBS maybe caused by... |
|
Definition
| cross reacting Abs to GM1 ganglioside formed in response to similar epitopes expressed by infectious agent |
|
|
Term
| Mechanisms other than _____ ______ may be associated with the production of Ab to GM1 ganglioside |
|
Definition
|
|
