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Microbiology Lecture 30 Vocab
Skin and Wound Infections
39
Biology
Undergraduate 2
04/07/2009

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Term
Furuncle
Definition

Boil

 

Lesion caused by S. aureus

 

Red swollen, inflammed area (hard center where bacteria grow w/pus)

 

Walled off by coagulase because the body clots blood plasma around the bacteria

Term
Folliculitis
Definition

Involves hair follicles

 

Mini boils in hair follicles that get infected

 

For especially after shaving

 

Caused by S. aureus

Term
Coagulase
Definition
An enzyme in the body that clots blood plasma around the bacteria (S. aureus)
Term
Bullous Exfoliation (SSSS)
Definition

Scalded skin syndrome

 

S. aureus that may present as a toxin disease

 

Exotoxin that dissolves the "glue" between the epidermis and dermis

 

Common in infants

Term
Toxic Shock Syndrome
Definition

Caused by S. aureus

 

Abrupt onset with fever, rash (from cytokines), hypotension (due to hypovolemea)

 

Caused by TSST superantigen toxin and causes a massive cytokine release

Term
Biofilm-Associated Infections
Definition

Caused by S. aureus and S. epidermis

 

Biofilm forms on implanted devices and creeps into the surrounding tissue

 

Want antibiofilm surfaces for implanted devices

Term
MRSA
Definition

Difficult to treat because of rapid development of multiple drug resistance (MDR)

 

Virulent staph infection

Term
Erysipelas
Definition

Streptococcal Infections

 

Infection of fat tissue underneath the skin

 

By the nerves, it is painful

 

Burning sensation, fever, chills

Term
Impetigo
Definition

Caused by Strep (also Staph, and others)

 

Crusts and blisters, fever

 

Could have ARF, AGN sequelae (autoimmune attack)?

 

AGN can cause acute glomerulonephritis

 

 

Term
Group A Strep (GAS)
Definition

Sensitive to PenG

 

S. pyrogenes

 

Spread by contact and respiratory droplets

Term
Lyme Disease
Definition

Caused by Borrelia burgdoferi (a spirochaete)

 

Spread via deer tick

 

Makes a "bull's eye" rash

 

Has late sequelae (antibodies attack the body) like heart abnormalities and arthritis

Term
Tetanus
Definition

"Lockjaw"

 

Caused by Clostridium tetani (anaerobic spore-former)

 

Mostly an intoxication (tetanospasmin)

 

Causes rigid paralysis, muscle contraction

Term
Tenanospasmin
Definition
What causes the intoxication of tenanus from Clostridium tetani
Term
Neuroinhibitor
Definition

A substance that binds to neuroreceptors to prevent the binding of neurotransmitters

 

Used in tetanus

Term
DTaP (DPT) vaccine/booster
Definition

Toxoid vaccine for tetanus

 

Need once every ten years because the memory cells die

Term
Tetanus Immune Globin (TIG)
Definition

Antitoxin that works if given early enough for tetanus

 

Tetanus shot

 

Too late if you wait for the symptoms

Term
Gangrene
Definition

Caused by Clostridium perfringens (and others)

 

1-3 days until an infected wound begins suppurating; foul discharge, tissue necrosis, toxemia, shock, death

 

Associated with traumatic tissue injury

 

Extracellular enzyme secretions detroy tissue and allow invasion of vegetative cells

 

No vaccine or antitoxin

 

Tissue trauma, impede blood flow, anaerobic, spores germinate and produce alpha toxin, destroys cellular structures

Term
Debridement
Definition
The medical removal of a patient's dead, damaged, or infected tissue to improve the healing potential of the remaining healthy tissue.
Term
Edematous Abscess
Definition

Inflammed, death of a tissue

 

E: inflammation and A: death of tissue

 

Can occur within a few hours of an animal bite caused by Pasteurella multocida

Term
Fowl cholera/ shipping fever/ snuffles
Definition

Infections caused by major animal pathogens (zoonosis)

 

Fowl cholera: from chickens, pneumonia

 

Shipping fever: from cattle, copious nasal discharge, septicemia, and acute pneumonia (death in 18 hrs)

 

Snuffles: from rabbit, leads to lethal hemorrhagic pneumonia

Term
Pyrogenic
Definition
Producing or produced by fever
Term
Lymphadenopathy
Definition

Lymph node swelling

 

Caused by cat-scratch disease by Bartonella henslae

Term
Varicella
Definition

Virus that causes chickenpox

 

Type of herpes virus (HHV3)

Term
Zoster
Definition

Latent virus that causes shingles that orginally caused chickenpox

 

Type of herpes virus (HHV3)

Term
Macular/ papular/ pustular
Definition

Diagnosis of chickenpox rash

 

macular: flat pink spots

 

Papular: rised

 

Pustular: puss

Term
Reye's syndrome
Definition

Secondary infection caused by chickenpox virus (varicella-zoter)

 

occurs in kids between the ages of 9-15

 

Associated with taking aspirin

 

Can cause coma or brain damage

Term
Rubeola (measles)
Definition

Caused by paramyxovirus

 

Fever, runny nose, fine red macular rash

 

Spread via respiratory droplets

 

Can also be a respiratory infection

Term
Cough, Coryza, Conjunctivitis
Definition

The three C's of measles that help diagnose the infeciton

 

Coryza: runny nose

 

Conjunctivitis: pink eye, inflammation of outer layer of eye and inner eyelids

Term
Koplik's Spots
Definition

Symptom of the measles

 

Spots in the pharynx

 

Spread via respiratory droplets

Term
MMR vaccine
Definition

Vaccine used for the measles

 

2-injection regimen, few years apart

 

Fewer than 100 cases/year in the US because of the vaccine

Term
Rubella
Definition

German Measles

 

Caused by togavirus

 

Slight fever, mild symptoms, fine rash

 

Respiratory transmission

 

VERY serious if vertical transmission (mother to fetus)

Term
Congential Rubella Syndrome
Definition

If mom has rubella and transmits to fetus

 

Causes blindness, deafness, heart disease, and retardation

Term
Papillomavirus
Definition

Spread via contact also with existing wart

 

Replicate in epithelial cell nuclei, cause abnormal cells (genital warts)

 

Plantar location can grow inverted due to pressure

 

Causes cervical cancer

Term
Gardasil
Definition
Vaccine used for some types of papillomaviruses
Term
Candidiasis
Definition

One of the fungal skin infections caused by Candida albicans (normal flora)

 

Causes diaper rash, thrush, and vaginal yeast infection

Term
Thrush
Definition

yeast infection that develops in the mouth and throat and on the tongue

 

Caused by Candida albicans

Term
Dermatophytic fungi
Definition

Fungal skin infection

 

Cutaneous skin infection

 

Causes athlete's foot and other "tinea" infections

 

Ringworm can cause this

Term
Ringworm (tinea corporis)
Definition

Type of dermatophyte

 

Causes a rough round patch (on cats?)

Term
Sporotrichosis
Definition

Punctures from plant thorns introduce spores

 

Spores turn into yeast

 

Nodules form along lymph vessel

 

Can rupture and cause secondary infections

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