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Microbiology Exam 3
Microbial Diseases
144
Biology
Undergraduate 1
04/14/2007

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Term
Pathogenicity
Definition
(qualitative) indicates bacterium can cause disease
Term
Virulence
Definition
(quantitative) measure of disease potential
Term
Upper Respiratory system consists of:
Definition
nose and throat (pharynx), including the middle ear and auditory tubes.
Term
Lower respiratory system consists of:
Definition
larynxs, trachea, bronchial tubes, and lungs.
Term
Microbial Diseases of Upper Respiratory System:
Definition
Streptococcus pyogenes
Corynebacterium diptheriae
Bordetella pertussis
Neisseria meningitidis
Hemophilus influenza
Term
Pharynigitis
Definition
sore, inflamed throat
Term
Laryngitis
Definition
inflammation of the larynx
Term
Tonsillitis
Definition
inflammation involving the tonsils
Term
sinusitis
Definition
infection of the paranasal sinus cavity
Term
Epiglottitis
Definition
inflammation of the flaplike structure of cartilage that prevents material from entering the larynx
Term
Streptococcal pyogenes
Definition
Virulence Factors:
Beta-hemolytic
M protein
Erythogenic "red forming" toxins
Term
Streptokinase
Definition
allows streptococci to escape from a fibrin clot
Term
Hyaluronidase
Definition
dissolves glue holding cells together. Hyaluronic acid is a major constituent of the intersitial space between cells
Term
Hemolytic classification of streptococci pyogenes:
Definition
Beta-hemolytic streptococci are surrounded by clear, colorless zone due to COMPLETE destruction of red blood cells.
Term
M protein
Definition
located in the cell wall and pili of streptococci. Encouraged adherence to pharynegeal (throat) tissue. Retards phagocytosis (white blood cells that try to kill the bacteria). Over 100 specific types of M protein have been identified.
Term
Streptococcus pyogenes causes:
Definition
Strep throat, by AIRBORNE DROPLETS expelled by coughing or sneezing.

Scarlet fever
Term
Symptoms of Strep Throat:
Definition
High fever, coughing, swollen lymph nodes and tonsils, fiery red throat. Complication- can also infect middle ear called otitis media
Term
Symptoms of Scarlet Fever:
Definition
Strep throat accompanied by a skin rash. Usually only get scarlet fever once because body makes antibodies against the toxin called Antitoxin
Term
Erythogenic toxin
Definition
"red forming" toxin produced by certain strains that carry prophage (ability of a cell to replicate) with toxin genes. Toxin damages capillaries results in blood leaking through the walls.
Term
Lytic
Definition
makes more phage
Term
Lysogeny
Definition
phage DNA integrates into chromosome and becomes dormant.
Term
Prophage
Definition
integrated viral genome
Term
Lysogens
Definition
cells with phage in the chromosome
Term
Induction
Definition
A change in environmental conditions can cause the prophage to come out of the chromosome. Results in phage entering LYTIC cycle and produces more phages.
Term
Scarlet Fever
Definition
Lysogenic strains of Streptococcus produce a extotoxin that results in:
Term
Diptheria
Definition
Lysogenic strains of COrynebacterium diptheriae produce a potent exotoxin that is the cause of:
Term
Botulinum toxin
Definition
Strains of Clostridium botulinum produce the:
Term
Rheumatic Fever
Definition
Characterized by fever and inflammation of the small blood vessels.
Term
Symptoms of Rheumatic fever:
Definition
Joint pain, often see permanent scarring and distortion of heart valves.
Term
Rheumatic Fever
Glomerulonephritis
Erysipelas
Definition
Results of untreated Streptococcal pharyngitis:
Term
Necrotizing Fasciitis
Definition
Very rare flesh-eating disease, streptococcus bacteria spread deep within the fascia, fibrous sheets of the connective tissue surrounding muscles and binding them to one another.
Term
Streptococcus pyogenes
Definition
Disease:Strep throat, streptococcal pharyngitis

Characteristics: Red pharyngeal lining, patches of pus, pain on swallowing, enlarge tonsils and lymph nodes
Term
Corynebacterium diptheriae
Definition
Disease: Diphtheria

Characteristics: Mild sore throat, slight fever swelling in neck, toxin production damages organs.
Term
Bordetella pertussis
Definition
Disease: Pertussis- Whooping Cough

Characteristics: Cold-like symptoms, mucus accumulates, intense spasms of coughing.
Term
Neisseria Meningitidis

Hemophilus Influenza
Definition
Disease: Meningitis

Characteristics: Membrane covering brain and spinal cord become inflamed. Primary to children under age 4. Severe headache, sudden high fever, stiff neck.
Term
Diptheria

Agent: Corynebacterium diptheriae
Definition
Virulence factors: swelling in neck with formation of pseudomembrane. Produces toxin which circulates and damages receptor-specific internal organs.
Term
Pseudomembrane
Definition
a membrane composed of dead human and bacterial cells
Term
Pertussis (whooping cough)

Agent: Bordetella Pertussis
Definition
Virulence factors: ciliary action is blocked by accumulations of dense masses of these bacteria in the trachea and bronchea. Toxins relesed upon bacterial cells death, and increases host's cytotoxin action causing eventual loss of ciliated cells.
Term
Pertussis

"Whooping Cough"
Definition
1st stage: resembles a common cold

2nd stage: paroxysmal (violent spells) stage is characterized by attempts to clear the throat by coughing

3rd stage: sporadic coughing for several weeks (100 days cough)
Term
Meninges
Definition
layers that cover both the brain and the spinal cord.
Term
Meningitis
Definition
An inflammation of the meninges
Term
Encephalitis
Definition
An inflammation of the brain
Term
Meningococol Meningitis

Agent: Neisseria Meningitis
Definition
Virulence Factors: attachment pili, endotoxin, capsule

Reservoir: Human asymptomatic carriers, nose and throat flora

Transmission: airborne droplets
Term
Microbial Diseases of Lower Respiratory System:
Definition
Tuberculosis
Pneumonia
Legionellosis
Q Fever
Psittacosis
Term
Mycobacterium tuberculosis
Definition
Disease: Tuberculosis

Characteristics: Chronic lung disease characterized by low-grade fever, and destruction of lung tissue
Term
Streptococcus Pneumoniae
Definition
Disease: Pneumonia

Characteristics: rust colored sputnum
Term
Tuberculosis
Definition
Chronic lung disease characterized by low grade fever, weight loss and destruction of lung tissue
Term
Tuberculosis

Agent: Mycobacterium tuberculosis
Definition
Acid fast positive, rod-shaped bacteria with a waxy cell wall that is resistant to drying and disinfectants. spread by aerosol droplets by people carrying the disease, spread by coughing, sneezing, speaking, or spiting
Term
Tuberculosis
Definition
Virulence factors: can survive phagocytosis living iside macrophages and moving with them to deep lung tissue. produces tubercle (small lumps).
Term
Tubercles
Definition
small lumps that are due to cellular immunity trying to limit the spread of the disease.
Term
Staphylcoccus aureus
Definition
Disease: G+ pnemonia

Characteristics: hospital acquired infection
Term
Haemophilus influenze
Klebsiella pneumoniae
Serratia Marcescens
Definition
Disease: G- pneumonia

Characteristics: compromised patients
Term
Mycoplasma pneumoniae
Definition
Disease: "walking pneumonia"

characteristics: primary atypical pneumonia
Term
Legionella pneumophilia
Definition
Disease: Legionellosis

Characteristics: spread by air
Term
Coxiella burnetii
Definition
Disease: Q Fever

Characteristics: Rickettsia, occurs dairy cows found in raw milk
Term
Chlamydia psittaci
Definition
Disease: psittacosis

Characteristics: Occurs in parrot and parrot like birds
Term
bronchitis or bronchiolities
Definition
infection affecting the bronchi
Term
pneumonia
Definition
general descriptive term which refers to the presence of fluid buildup in the lungs.
Term
Lobar pneumonia
Definition
pneumonia that affects an entire lobe of the lung
Term
Double pneumonia
Definition
Pneumonia that affects both left and right lungs
Term
Bronchopneumonia
Definition
infection in the bronchiole respiratory passage
Term
Nosocomial pneumonia
Definition
main causes of pneumonia that occurs in the hopsital
Term
Pleomorphic (Mycoplasmal Pneumonia)
Definition
having no cell wall, cannot be treated with cell wall affecting antibiotics (penicillins)
Term
Legionnaires disease
Definition
Agent: Legionella pneumophilia

Virulence factors: can survive phagocytosis in compromised hosts, causes abscesses and tissue death.

Reservoir: grows in water of air-conditioning cooling towers

Symptoms: fever, dry cough with little sputum, some diarrhea and vomiting
Term
Q Fever
Definition
Agent: Coxiella Burnetii

grows only within living tissue. Causes mild respiratory disease lasting 1-2 weeks.

Symtoms: sever headache, high fever, a dry cough.

Treatment: Tetracycline
Term
Q Fever
Definition
Prevalent in livestock especially dairy cows, goats, and sheep due to a parasite . Humans get it by ingesting unpasteurized milk and by inhaling aerosols of microbes in dairy barns.
Term
Psittacosis
Definition
Affects parrots, parakeets, and other birds. Transmitted by inhaling airborne dust or dried droppings of infected birds.
Term
Clostridium Botulinum
Definition
Disease: Botulism

Characteristics: Exotoxin causes paralysis and respiratory failure
Term
Staphylococcus aureus
Definition
Disease: Staphylococcal food poisoning

Characteristics: Enterotoxin causes cramps, nausea, vomiting and diarrhea
Term
Clostrium perfringens
Definition
Disease: Clostridium food poisoning

Characteristics: Enterotoxin causes cramps, abdomain pain and watery diarrhea
Term
Bacillus cereus
Definition
Disease: Bacillus cerus food poisoning

Characterisitcs: Enterotoxin causes cramps, diarrhea and vomiting.
Term
Enterotoxin
Definition
Toxin involved in gastrointestines
Term
Botulism
Definition
Agent: Clostridium botulinum

Reservoid: Endospores found in intestines of humans and animals

Virulence Factor: produces an exotoxin that acts on nerves to block neuromuscular synapse transmission.
Term
Fodder Disease
Limber-neck
Would botulism
Infant botulism
Definition
Botulism is known to cause:
Term
Staphylcoccal Aureus
Definition
Mode of transmission: errant sneeze onto food. Skin infection (pimples, boils, abscesses)
Term
Foodborne and Waterborne INTOXICATIONS
Definition
Botulism
Staphylococcal food poisoning
Clostridium food poinsoning
Bacillus cerus food poinsoning
Term
Foodborne and Waterborne INFECTIONS
Definition
Typhoid fever
Salmonellosis
Salmonellosis
Shigellosis
Cholera
E. Coli
Peptic Ulcers
Campylobacterosis
Listeriosis
Brucellosis
Term
Typhoid Fever
Definition
Agent: Salmonella typhi

Reservoir: only humans

Transmission: Flies, food, fingers, feces, fomites
Term
Typhoid Fever
Definition
Symptoms: high fever, continual headahce,fever declines and diarrhea appears
Term
gallbladder
Definition
Recovered patients of Typhoid Fever become chronic carriers because they harbor the microbe in their __________
Term
Salmonellosis
Definition
Agent: Salmonella enterica and its serotypes

Reservoir: Intestinal tracts of humans and animals
Term
Salmonellosis
Definition
Infection of the intestinal tract
Term
Salmonellosis
Definition
Symptoms: Diarrhea, stomach cramps, nausea and vomiting, some people can have no symptoms at all
Term
Shigellosis
Definition
Agent: Shigella species
Term
Shigellosis
Definition
a syndrome manifested byy waves of intense abdominal cramps and frequent passage of small-volume, bloody mucoid stools
Term
Shigella dysenteriae
shigella sonnei
Definition
Tropical area disease:______________
U.s. diarrhea: _____________
Term
Shigellosis
Definition
Transmission: Humans ingest the organism from feces or contaminated water. Sometimes from vegetables, eggs, shellfish, and dairy products
Term
Cholera
Definition
Agent: vibrio cholerae

Resevoir: contaminated water or food such as raw oysters

Virulence Factors: produces an enterotoxin
Term
Cholera
Definition
Symptoms: extensive diarrhea, rice-water stools, sudden loss of fluid and electrolytes causes shock, collapse, and often death.
Term
Cholera
Definition
There is a seventh world wide pandemic of ___________ still going on today
Term
Escherichia Coli
Definition
Disease: E. Coli Diarrheas

Characteristics: watery diarrhea typical traveler's diarrhea
Term
Helicobacter pylori
Definition
Disease: Peptic Ulcers

Characteristics: adapted to survive in stomach
Term
Campylobacter jejuni
Definition
Disease: Campylobacterosis

Characteristics: Gastroenteritis from raw milk
Term
Listeria Monocytogenes
Definition
Disease: Listeriosis

Characteristics: Main danger to fetus, transmitted contaminated food
Term
Brucella species
Definition
Disease: Brucellosis

Characteristics: Undulant fever. Animal workers
Term
E. Coli
Definition
Agent:Escherichia coli

Reservoir: One of the most prolific microorganisms in humans and other animals intestinal tracts
Term
E. Coli
Definition
Virulence Factors: Pathogenic strains have specialzed fimbriae that allows them to bind to certain intestinal epithelial cells can be ENTEROTOXIC or ENTEROINVASIVE
Term
Enterotoxic strans
Definition
(non-invasive) produce a enterotoxin similar to cholera which induces fluid loss in small intestine.
Term
Enteroinvasive strains
Definition
penetrate the intestinal epithelium, as in shigellosis, which primarily damages the large intestines
Term
Traveler's Diarrhea (Montezuma's revenge)
Definition
Victims experience diarrhea within 2 weeks of traveling and the diarrhea lasts from 1 up to 10 days.
Term
Peptic Ulcer

Ammonia and carbon dioxide
Definition
Agent: helicobacter pylori

Virulence factors: able to survive intense acidity of the stomach, secretes enzyme urease, which splits urea into ____________ and ____________.
Term
Peptic Ulcer
Definition
can be determined by a breath test
Term
Campylobacteriosis
Definition
Agent: Campylobacter jejuni

Reservoirs: intestinal tracts of many animals including dairy cattle, chickens and turkey. Effects poultry
Term
Listeric meningitis
Definition
characterized by headaches, stiff neck, delirium and coma
Term
M protein
Definition
Streptococcus pyogenes produces a protein that, anchored in the cell wall and cell membrane, allows bacterial cells to adhere to teh pharyngeal tissue. This protein is called:
Term
Neisseria meningitidis
Definition
A 1 year old female was hospitalized with fever, lethargy and rash. Gram-negative, oxidase-positive cocci were cultured from her cerbrospinal flued. Her symptoms were caused by:
Term
Waterhous-Friderichson syndrome
Definition
In some cases of meningococal meningitis, hemorrhagic lesion form in the adrenal glands, causing hormonal imbalance. This condition is called:
Term
usually acquired in the hospital
Definition
Nosocomial infections are those that are:
Term
gram negative rod
Definition
Legionarrie's disease is characterized by a gram-___________, ________.
Term
Mycoplasma pneumoniae
Definition
The agent of primary atypical pneumonia is:
Term
accumulates in water
Definition
Cases of legionnaire's disease have been linked to bacteria which
Term
Q Fever
Definition
a rickettsial disease associated with livestock animals
Term
have no cell wall
Definition
Penicillin is useless for the treatment of mycoplasma pneumonia because the causitive organism
Term
Mycobacterium tuberculosis
Definition
_______________ does not produce a toxin
Term
pneumococcal pneumonia
Definition
A patient has fever, difficulty breathing, chest pains and fluid in the alveoli. Gram-positive cocci were isolated from the sputum. The patient most likely has
Term
a skin rash on the palms and soles
Definition
The diagnosis of tuberculosis is aided by
Term
diptheria and scarlet fever
Definition
Bacteriophages have been located in a lysogenic relationship with the causative organisms of
Term
respiratory disease in compromised patients
Definition
serratia marcescens is currently considered to be a cause of
Term
bordetella pertussis
Definition
A child suffering from repeated bouts of a violent, high pitched cough is brough to her physican who will diagnose her infection as
Term
strep throat
scarlet fever
puerperal fever
Definition
Streptococcus pyogenes causes these diseases
Term
Erythogenic toxin
Definition
produced by Streptococcus pyogenes and damages the capillaries
Term
mycoplasma pneumonia
Definition
A pleomorphic organism with no cell wall that causes a type of pneumonia is
Term
gram-negative diplococci in spinal fluid
Definition
An important principal criterion form the diagnosis of meningococcal meningitis is
Term
Baccilus Cereus
Definition
An organism commonly present in air and soil that has been a concern with cooked rice that has been standing at room temperature
Term
cause of food poisoning
Definition
Clostridium perfringens has recieved notoriety in recent years as an important
Term
work in dairy herds
Definition
Brucellosis is an occupational hazard of those qho
Term
the person is intoxicated rather than infected
Definition
Antibiotics are of no value in treating botulism because
Term
Campylobacter jejuni
Definition
Poultry products are a likely source of infection by
Term
replacement of lost fluids
Definition
The important consideration in treating patients who have bacterial dysentery is
Term
E. Coli
Definition
The most common cause of traveler's diarrhea is probably
Term
Cholera
Definition
No diarrhea can compare with the extensive diarrhea associated with
Term
Water and electrolytes
Definition
most gastrointestinal infections are treated with
Term
can be immunized against it
Definition
Travelers to cholera regions of the world
Term
staphylococcal
Definition
the _____________ enterotoxin is produced in the human intestine
Term
gall bladder
Definition
After recovery from typhoid fever, the carriers may harbor the organism in their
Term
still going on today
Definition
The last pandemic of Asiatic cholera is
Term
R factors
Definition
extra-chromosomal elements that contain drug-resistant genes
Term
inhibiting the release of acetylcholine
Definition
botulism toxin acts by
Term
Clostridium botulinum
Definition
Probably the most potent toxin known is produced by
Term
breath test
Definition
H. pylori can be detected by which of the following methods:
Term
educate people to methods of sanitation and personal hygiene
Definition
One of the most important factors in controlling foodborne and waterborne disease is to
Term
Typhoid fever
Definition
The antibiotic ceftriaxone is used to treat
Term
Salmonilla enterica serotypes
Definition
disease that can be spread by household pets like ducks, tortoises and iguanas
Term
Salmonilla enterica serotypes
Definition
disease that can be spread by household pets like ducks, tortoises and iguanas
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