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Microbiology Drugs 3
Step 1 Review: Helminths
18
Biology
Graduate
12/24/2007

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Cards

Term
Name the 5 Nematodes
Definition

1.  Trichuris trichiura

2.  Ascaris lumbricoides

3.  Toxocara canis

4.  Necator americanus 

5.  Strongyloides stercoralis 

Term
Name the 3 "bendazoles" used for Nematode treatment
Definition

1.  Mebendazole

2.  thiabendazole

3.  Albendazole 

Term
What's the mechanism of action of Mebendazole
Definition
Irreversible inhibition of glucose uptake
Term
What's the mechanism of action for Thiabendazole & Albendazole
Definition
Inhibits polymerization of beta-tubulin into microtubules
Term
What's the common adverse effects of the "bendazoles"
Definition
GI discomfort
Term
Pyrantel is a _______ NMJ blocking agent
Definition
Depolarizing
Term
What's the spectrum of Pyrantel
Definition
Broad spectrum for Nematodes
Term
Name the 6 Cestodes
Definition

1.  Taenia solium

2.  Taenia saginate

3.  Diphyllobothrium latum

4.  Echinococcus species

5.  Diphyllobothrium latum 

Term
What's the mechanism of action for Nicosamide?
Definition

1.  Inhibits anaerobic metabolism

2.  Digest scolex

 

Term
What's the spectrum of Nicolsamides?
Definition
Common cestodes
Term
Nicolsamide is the first choice drug for _______ except ________
Definition

1.  Common tapes worms

2.  Pork tapeworms 

Term
What should you avoid when taking Niclosamide
Definition
Alcohol
Term
What's the first line agent against trematodes & cestodes
Definition
Praziquantel
Term
What are the adverse effects of Praziquantel?
Definition

1.  Ab. pain

2.  Diarrhea

3.  Headache 

Term
What is the drug of choice for the treatmetn of fascioliasis hepatica
Definition
Bithionol
Term
Name the 4 Trematodes "fluke"
Definition

1.  Schistosome species

2.  Clonorchis sinensis

3.  Paragonimus westermani 

4.  Fascioliasis hepatica 

Term
What is the serious adverse effect of Bithionol?
Definition
Toxic hepatitis or leukopenia
Term
Can you use Praziquantel to treat Trematodes?
Definition
Yes, it's the most common one used
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