Term
| Chloroquine disrupts ________ __ _______& kills the parasite by _________ _________ to membranes, digestive proteases |
|
Definition
1. Polymerization of heme 2. Oxidative damage |
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Term
| Resistance to Chloroquine can be seen in _____ & increasing in _______ |
|
Definition
1. P. falciparum 2. P. vivax |
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|
Term
Adverse effects for Chloroquine |
|
Definition
1. Gi distress 2. dizziness 3. Major: Retinopathy |
|
|
Term
| Contraindication for Chloroquine |
|
Definition
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|
Term
| Which Malaria drug would you use for prophylaxis |
|
Definition
|
|
Term
| What adverse effect does Mefloquine have on the CVS |
|
Definition
|
|
Term
| Other than prophyaxis when would you use Mefloquine |
|
Definition
| For chloroquine resistant P. falciparum & P. vivax |
|
|
Term
| Quinine sulfate is used as a first agent for |
|
Definition
|
|
Term
| What contraindications are there for Quinine |
|
Definition
|
|
Term
| What major adverse effect do you see in Quinine |
|
Definition
1. Hemolytic anemia 2. Renal damage 3. Agranulocytosis 4. Hypoglycemia |
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|
Term
| Primaquine is the drug choice for _______ |
|
Definition
| Dormant liver forms of p. vivax and p. ovale |
|
|
Term
| What contraindications are there for Primaquine |
|
Definition
1. Pregnancy 2. G6PD deficiency 3. Autoimmune |
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|
Term
What adverse effects are there for Primaquine (4) |
|
Definition
1. GI distress 2. Heacaches 3. Pruritus 4. Methemoglobinemia |
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|
Term
| What does Nifurtimox inhibit and what is it essential for? |
|
Definition
1. Trypanothione reductase 2. thiol metabolism & survival |
|
|
Term
| When would you use nifurtimox |
|
Definition
| Trypansoma cruzi "American sleeping sickness" |
|
|
Term
What are the adverse effects of Nifurtimox (3) |
|
Definition
1. GI irritation 2. Allergies 3. CNS toxicities |
|
|
Term
Which drug is used for Treatment of Trypanosoma gambiense & rhodesiense "Afrian sleeping sickness"
|
|
Definition
|
|
Term
| What is Melarsoprol limited to trypansomal infections? |
|
Definition
|
|
Term
| What are the severe side effects of Melarsoprol |
|
Definition
| 1. CNS toxicity such as encephalopathy |
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|
Term
| Sodium stibogluconate is used in _____ |
|
Definition
|
|
Term
| Sodium stibogluconate is required to be reduced to ________ ________ ________ in vivo that is essential for _____ |
|
Definition
trivlanet antimony compound activity |
|
|
Term
| What are the adverse effects of Sodium Stibogluconate |
|
Definition
Cardiac arrhythmias Monitor renal & hepatic function |
|
|
Term
| What enzyme does Pyrimethamine inhibit in Toxo? |
|
Definition
|
|
Term
| When during pregnancy should one use Pyrimethamine |
|
Definition
| Late and if the baby is born w/ it |
|
|
Term
| What 3 drug combination would you give if a baby has toxo |
|
Definition
1. Pyimethamine 2. sulfadiazine 3. Folic acid |
|
|
Term
| Which 3 protozons do you use Metronidazole |
|
Definition
1. Amebiasis 2. giardiasis 3. Trichomonasis |
|
|
Term
| How does Metronidazole work? |
|
Definition
| it forms a reactive cytotoxic product to interfere w/ energy metabolism pathway |
|
|
Term
| What are the adverse effects of Metronidazole |
|
Definition
1. Metallic taste 2. Peripheral neuropathy 3. Alcohol intolerance |
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