Term
|
Definition
CNS (oligodendrocytes)
Demyelination |
|
|
Term
| Acute Idiopathic Polyneuritis |
|
Definition
Guillian-Barre syndrome
Peripheral nerves - paralysis!!
Demyelination |
|
|
Term
|
Definition
Neuromuscular junction; acetylcholine receptor attacked
muscle weakness
destruction or blocking of acetylcholine receptor; impaired transmission |
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Term
|
Definition
| thyroid - hypothyroidism anti-thyroglobulin; anti-thyroid epithelium |
|
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Term
|
Definition
thyroid - hyperthyroidism
anti-TSH receptor (thyroid stimulating hormone) |
|
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Term
|
Definition
basement membranes of renal glomeruli
kidneys and lungs fail |
|
|
Term
|
Definition
adrenal glands affected
anti-adrenal cell membranes and lymphocyte/monocyte cortical infiltration |
|
|
Term
| insulin-dependent diabetes mellitus |
|
Definition
pancreatic islets (beta cells)
beta cells get destroyed! |
|
|
Term
|
Definition
salivary glands
glandular inflammation |
|
|
Term
| autoimmune hemolytic anemia |
|
Definition
erythrocytes affected
they are destroyed, resulting in anemia |
|
|
Term
|
Definition
platelets or megakaryocytes affected adversely
platelets destroyed resulting in abnormal bleeding |
|
|
Term
| chronic atrophic gastritis; pernicious anemia |
|
Definition
affects gastric mucosa
loss of gastric secretory function (can't release acidic proteins! - imp immune defense)
failure of vitamin B12 absorption due to loss of intrinsic factor or intrinsic factor producing cells
results in chronic atrophic gastritis |
|
|
Term
| Intestinal granulomatous Disease (IGD) - Crohn's disease |
|
Definition
another malabsorption problem (this time in mucosal membrane of terminal ileum)
mucosal ulceration; obstructive granuloma (immune system tries to wall it off)
type IV HS |
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|
Term
|
Definition
affects heart
causes myocarditis; scarring of heart valves |
|
|
Term
|
Definition
affects epidermis
blistering of skin |
|
|
Term
| systemic lupus erythematosis |
|
Definition
affects EVERYTHING
acute immune complex disease (type 3 HS) |
|
|
Term
|
Definition
affects joints, spreading to cartilage and neighboring bone and muscle
immune complex disease in synovium (fluid of joints); antibodies (RF) against IgG prominent Inflammatory T cells noted |
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