Term
| What is the one family of dsRNA viruses called? What is wierd about them? What are the family members and what do they cause? |
|
Definition
Reoviruses
-*Rotavirus
-Reovirus
-Colorado tick fever virus (CTFV)
-They are (-)dsRNA with *10-11 segments, they have a *polymerase, they are **naked (fecal-oral potential), and have a double icosahedral shell |
|
|
Term
| What illnesses do the members of reovirus cause? How are they transmitted |
|
Definition
-*Rotavirus; *infantile gastroenteritis (fecal-oral)
-Reovirus; common cold, gastroenteritis (fecal-oral)
-CTFV; flu-like illness and possible rash (ticks)
-Treatment for theses is all supportive |
|
|
Term
| Give the five viruses studied that are associated with cancer and the type they cause? |
|
Definition
-EBV; burkitt lymphoma (c-myc translocation in B cells)
-Chronic HBV & HCV; primary hepatocellular carcinoma
-HPV; cervical carcinoma
-HTLV-1&2; leukemias |
|
|
Term
| The biggest prion disease is Creutzfeldt-Jakob disease, what do we have to differentiate it from? |
|
Definition
-It causes slow neural degeneration similar to a few others;
-Measles subacute sclerosing panencephalitis (SSPE)
-AIDS dementia
-Progressive multifocal leukoencephalopathy from JC virus (only really seen in AIDS patients)
-For the first one, we would have had measles
-The second two, we will be HIV positive |
|
|
Term
| What is phenotypic mixing? What is part of that? |
|
Definition
-When you have a confection where the two viruses can mix phenotypes
-An example of this is phenotypic masking where a virus ends up with the wrong capsid (of the other virus) |
|
|
Term
|
Definition
-It is one where we have a defective gene that becomes active after introduction of a coinfection that supplies the defective function (has the same, but working gene)
-Im not sure, but Hep D might be an example; it needs a coinfection with Hep B, and then it is fatal |
|
|
Term
| What is genetic shift vs. drift? |
|
Definition
-The shift is from animal + human in the same cell that makes a new super virus; seen in influenza A
-Drift is because RNA pol sucks; most notable in influenza and HIV |
|
|
