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Micro-Unit 3
Chapter 14
41
Microbiology
Undergraduate 2
06/18/2011

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Term
Infection
Definition
The growth of a microorganism in the body.
Term
Disease
Definition
An abnormal state in which part or all of the body is not properly adjusted or is incapable of performing normal functions; any change from a state of health.
Term
Infectious Disease
Definition
A disease in which pathogens invade a susceptible host and carry out at least part of their life cycle in the host.
Term
Pathogenic
Definition
The ability to cause a disease by overcoming the defenses of the host.
Term
Virulence (virulent, avirulent)
Definition
The degreee of pathogenicity of a microorganism.
Term
etiology
Definition
The study of the cause of a disease.
Term
Normal Microbiota (normal flora)
Definition
The microorganisms that colonize a host without causing disease
Term
Transient Flora
Definition
The microorganisms that are present in an animal for a short time without causing a disease.
Term
Microbial Antagonism (competitive exclusion)
Definition
Growth of some microbes prevents the growth of other microbes.
Term
Symbiosis
Definition
The living together of two different organisms or populations.
Term
Opportunists
Definition
Microorganisms that do not ordinarily cause a disease, but become pathogenic under certain circumstances.
Term
Koch's Postulates
Definition
I. the same pathogen must be present in every case of the disease.
II. the pathogen must be isolated from the diseased host in pure culture
III. the pathogen must cause the same disease in a susceptible test animal.
IV. the pathogen must be re-isolated from the test animal and documented as the same organism.
Term
Symptoms
Definition
A change in body function that is felt by a patient as a result of a disease.
Term
Signs
Definition
A change due to a disease that a person can observe and measure
Term
Syndrome
Definition
A specific group of signs or symptoms that accompany a disease.
Term
Communicable Disease
Definition
Any disease that can be spread from one host to another.
Term
Contagious Disease
Definition
A disease that is easily spread from one person to another.
Term
Noncommunicable Disease
Definition
A disease that is not transmitted from one person to another.
Term
Epidemic
Definition
Unusually large number of cases in short period of time
Term
Endimic
Definition
a disease present constantly in a community in relatively stable numbers
Term
Pandemic
Definition
an epidemic of world-wide occurence
Term
Sporadic
Definition
a disease that occurs as occasional cases
Term
Disease- Acute, chronic, subacute, latent
Definition
Acute Disease- a disease in which symptoms develop rapidly but last for only a short time.

Chronic disease- A disease that develops slowly and is likely to continue or recur for long periods.

Subacute Disease-

Latent Disease
Term
Herd Immunity
Definition
The presence of immunity in most of a population
Term
Local Infection
Definition
An infection in which pathogens are limited to a small area of the body.
Term
Systemic (generalized) Infection
Definition
An infection throughout the body.
Term
Focal Infection
Definition
A systemic infection that began as an infection in one place.
Term
Bacteremia
Definition
A condition in which there are bacteria in the blood.
Term
Septicemia
Definition
The proliferation of pathogens in the blood, accompanied by fever; sometimes causes organ damage.
Term
Toxemia
Definition
The presence of toxins in the blood.
Term
Viremia
Definition
The presence of viruses in the blood.
Term
Primary Infection/Secondary Infection
Definition
An acute infection that causes the initial illness.

An infection caused by an opportunistic microbe after a primary infection has weakened the host's defenses.
Term
Inapparent or Subclinical Infection
Definition
An infection that does not cause noticeable illness.
Term
Predisposing Factors for Infectious Disease: Compromised Host
Definition
age, genetic background, gender, pre-existing illness, nutrition, fatigue, lifestyle or occupation, chemotherapy, stress, habits
Term
Stages of Disease
Definition
1. Contact- contact w/pathogen at successful portal of entry in sufficient numbers.
2. Incubation- time between contact and onset of symptoms.
3. Prodromal- brief period of nospecific signs and symptoms.
4. Acute- period of illness and specific signs and symptoms
5. Decline- decline of signs and symptoms- crisis or lysis.
6. Convalescence- period of recovery.
Term
Reservoirs of Infection: Source of Organism for Infection (where?)
Definition
1. Human- carriers either symptomatic or asymptomatic (AIDS, syphilis, Herpes, typhoid fever, hepatitis)
2. Animals- domestic or wild- zoonosis, anthrax, Rocky Mt. Spotted Fever, Lyme disease, rabies
3. Non-Living- Soil & Water- ringworm, botulism, tetanus, Legionellosis
Term
Methods of Disease Transmission (How?)
Definition
1. Contact- direct contact, indirect contact (fomite transmission), droplet (short distance- influenza, whooping cough)

2. Vehicle- waterborne, foodborne, airborne (longer distance >1 meter- tuburculosis, staphylococci, histoplasmosis)

3. Vectors- mechanical(passive transport), biological (active process- bites)
Term
Nosocomial Infections
Definition
Infections acquired as a result of a hospital stay. 5-15% risk, approx. 2 million people in the US develop nosocomial infection per year with nearly 90,000 deaths.

3 contributing factors: microorganisms in the hospital environment, compromised hosts, chain of transimission
Term
Emerging Infectious Disease (EID)
Definition
A new or changing disease that is increasing or has the potential to increase in incidence in the near future.
Term
Epidemiology
Definition
The science that studies when and where diseases occur and how they are transmitted.
Term
Notifiable Disease
Definition
A disease that physicians must report to the US Public Health Service; also called a reportable disease.
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