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Micro and Macro Nutrients
Pharmacotherapy Fall 2013 Exam 1
128
Pharmacology
Professional
09/14/2013

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Term
macronutrients
Definition
provide calories and energy, are required in large amounts
Term
proteins, carbs and fats
Definition
macronutrients
Term
micronutrients
Definition
required in small quantities; vitamins and minerals
Term
vitamins
Definition
contain carbon (organic)
Term
water soluble micronutrients
Definition
b-complex, vitamin C
Term
fat soluble micronutrients
Definition
ADEK
Term
mineral micronutrients
Definition
inorganic (no carbon): ca, mg, k, zn, fe, s, I, Phos...etc.
Term
CHO intake should be
Definition
30-50% of diet
Term
CHO
Definition
primarily energy production, provides zip code used to ship proteins in/out of cells
Term
essential for fat breakdown; oxalacetic acid oxidizes fat
Definition
CHO
Term
fiber
Definition
type of CHO; promotes beneficial gut bacterial and intestinal peristaltic movements
Term
brain
Definition
uses 30-50% of daily blood glucose
Term
20-35% of glucose just to fuel RESTING metabolic rate
Definition
Brain function
Term
too little fuel
Definition
fatigue, depression and poor academic performance
Term
body stores 1.5-3lbs of CHO in the form of
Definition
glycogen
Term
brain needs at least
Definition
100-150g CHO/day
Term
1 lb equals
Definition
2000 calories
Term
glycomimetics
Definition
low molecular weight drugs which mimic CHO recognition molecules
Term
examples of glycomimetics
Definition
tamiflu (oseltamivir) and Relenza antivirals, glucobay (Acarbose), Glyset (Miglitol) and Glustat (Voglibose)
Term
Alpha-glucosidase (brush border enzyme) and/or alpha-amylase (pancreatic CHO enzyme) inhibitors; Prevents starches from being broken down to sugar (potential problems?)
Definition
Glucobay (Acarbose) and Glyset (Miglitol) and Glustat (Voglibose) treat diabetes
Term
Tamiflu (oseltamivir) and Relenza
Definition
Neuraminidase (glycoprotein) inhibitors prevent viral detachment
Term
higher risk of cognitive impairment
Definition
too much dietary CHO
Term
high blood glucose
Definition
increases risk of dementia and brain shrinkage
Term
consuming 15% more protiens
Definition
curbs excess snacking
Term
protein intake
Definition
15-35% of daily calories
Term
essential AA's
Definition
cannot be made by the body
Term
non-essential AA's
Definition
can be made from other AA's
Term
complete protein foods contain all the essential AA's
Definition
meat, milk, eggs
Term
incomplete protein foods contain only some essential AA's
Definition
grains and legumes (beans/peas/lentils etc.)
Term
protein builds
Definition
muscle, tissue, bone, neurotransmitters, enzymes, cell recognition, immune system and also 'zip code'
Term
contains nitrogen
Definition
ONLY protein
Term
too little protein
Definition
food cravings, tiredness, muscle/joint pain, slow healing, EDEMA, feeling cold
Term
fat intake
Definition
25-40% daily calories
Term
fats important for
Definition
energy storage, myelin in nerves, cell membranes, hormones, neuortransmitters (and receptors), phospholipids
Term
600 different types of
Definition
lipids in human plasma alone
Term
membrane lipids regulate
Definition
over 30% of cellular protein interactions
Term
lipid involvement in cellular signaling pathways are responsible for
Definition
cancer, diabetes and other metobolic disorders
Term
fat is vital for
Definition
hormone formation, NT and neuron productions as well as absorption of Vit. ADEK
Term
fat builds your
Definition
brain and neural communications
Term
body can be trained to burn
Definition
fat or carbs as fuel (fat more efficiently)
Term
one pound of fat equals
Definition
3500 Kcal
Term
olympic athletes
Definition
5000-12000 Kcal
Term
1900 century workers and farmers
Definition
5000-12000 Kcal
Term
modern office workers
Definition
1800-3500 Kcal
Term
meeting energy needs does not equal
Definition
meeting nutritional needs
Term
Enzymes and molecules used in metabolic pathways have
Definition
vitamin and mineral cofactors, activators and associations
Term
energy redox molecules
Definition
NAD/NADH2 (niacin), NADP/NADPH (niacin) and FAD/FADH (riboflavin)
Term
high energy electrons are removed from food carbon molecules that are
Definition
picked up by redox molecules; niacin, riboflavin
Term
Redox molecules flow to the
Definition
electron transport chain in the mitochondria
Term
food energy in the form of electrin and protons are used to
Definition
make an electrochemical gradient
Term
ETC provides energy to pump protons
Definition
that create a gradient which facilitates ATPase that make ATP and ADP + phos
Term
ETC electron carriers include
Definition
coenzyme Q-10, iron, sulfur and Copper
Term
environmental control of genes
Definition
methylation (gene expression), Histone acetylation, histo biotinylation, among other modifications
Term
what you eat
Definition
changes your genetic makeup (cofactors from diet help facilitate gene modification)
Term
ideal diet for human health
Definition
1/3 carbs, 1/3 protein, and 1/3 fat
Term
energy production
Definition
B-complex, magnesium, vit. C
Term
antioxidants
Definition
vit A, E and C, selenium, MANGanese superoxide dismutase (MnSOD)in mitochondria
Term
electrolyte balance
Definition
sodium and potassium
Term
muscle and nerve transmissions
Definition
calcium and magnesium
Term
oxygen transport and regulation
Definition
iron
Term
gene regulation
Definition
vit. A and D
Term
B-complex vitamins is found in
Definition
mean, eggs, milk, fish, whole grains, legumes, leafy greens
Term
B12
Definition
only found in animal products
Term
B-complex includes
Definition
folic acid, niacin, B12 (cobalamins), B6 (pyridoxine), pantothenic acid, riboflavin, thiamin, biotin, choline
Term
B12
Definition
cobalamins
Term
B6
Definition
pyridoxine
Term
B vitamins
Definition
involved in energy production, epigenetics, metabolism, and homocyseine metabolism
Term
Folic Acid important for
Definition
hemoglobin, one-carbon metabolism, regulation of homocysteine
Term
folic acid deficiency
Definition
neural tube defects, anemia, CA risk
Term
niacin important for
Definition
reduced LDL cholesterol, treats, atherosclerosis, hormone production
Term
deficiency in Niacin
Definition
pellagra, depression, fatigue
Term
B12 (cobalamin) is important for
Definition
nervous system, cell division
Term
B12 deficiency
Definition
anemia, dementia, severe neurological problems
Term
yellow pigment in urine if taking too much
Definition
B vitamins
Term
B6 (pyridoxine) is important for
Definition
metabolism of AA's and fats, red blood cell production
Term
B6 deficiency
Definition
anemia, skin lesions, oily/ flaky skin, cracked dry lips, glossitis (inflammed tongue), depression, confusion
Term
pantothenic acid
Definition
coenzyme A used in energy production pathways, alters 3D protein function and gene expression
Term
rarely seen as deficiency
Definition
pantothenic acid
Term
riboflavin (B2) is important for
Definition
metabolizing fats and carbs (FAD, FMN), boosts antibodies, cellular growth and repair
Term
deficiency of riboflavin (B2)
Definition
ariboflavinosis, soreness and cracks near mouth, glossitis, anemia (due to its role in converting B6 to active form)
Term
thiamin (B1) is important for
Definition
energy metabolism, HCL production in stomach, heart function, nerves, muscles, thiamin pyrophosphate (TPP) required coenzyme in food energy pathways
Term
deficiency in thiamin
Definition
common among alcoholics, loss of appetite, heart enlargement, mental confusion, Beriberi (muscle weakness, pain, neurologic parasthesia, death)
Term
biotin importance
Definition
attaches at the active site of carbocylase enzymes essential for gluconeogenesis, fatty acid synthesis and metabolism
Term
deficiency of biotin
Definition
hair loss, scaly facial rash, hallucination, depression
Term
vitamin C is found in
Definition
fruit and veggies
Term
functions of vitamin C
Definition
antioxidant, helps in carnitine synthesis (essential for beta-oxidation or fat burning), collagen production
Term
mild deficiency of Vit. C
Definition
fatigue, irritability, hemorrhagin, joint pain, illness and loose teeth
Term
major deficiency of Vit. C
Definition
scurvy and death
Term
13-23% of US population is deficient in what vitamin
Definition
Vit. C
Term
vitamin A is found in
Definition
yellow, orange, red fruits and veggies, fortified milk and eggs
Term
function of vitamin A
Definition
vision (rhodopsin), growth, immune system, red blood cell production, iron incorporation into hemoglobin
Term
deficiency in vitamin A
Definition
weak muscles, immunodeficiency, abnormal cell proliferation, blindness and death
Term
250 million children are vitamin A deficient
Definition
of that 1/3-1/2 million become blind each year
Term
retinoic acid
Definition
acts as hormone (like vit. D), regulates gene transcription, and cellular differentiation (specialization of cells for highly specific physiological roles)
Term
vitamin D is found in
Definition
fatty fish (salmon), fortified dairy and the sun!
Term
UVB rays trigger synthesis of Vit. D from cholesterol in skin
Definition
then it is sent to the liver/kindneys where it is activated to 1,25-dihydroxyvitamin D
Term
functions of Vit. D
Definition
maintain calcium balance in body, cell differentiation, immune system, blood pressure regulation
Term
in the presence of 1,25-dihydroxyvitamin D, the vitamin D receptor/RXR complex binds small sequence of DNA
Definition
which modulate the transcription of over 50 genes
Term
deficiency of Vit. D
Definition
sleep disorders, depression, rickets in children and soft bones in adults
Term
70% of children in the US are deficient in what vitamin
Definition
vitamin D
Term
calcium is found in
Definition
dairy, fish canned with bones, spinach and white beans
Term
functions of calcium
Definition
bone health, blood vessel constriction and relaxation, cellular signaling and skeletal muscle/ nerve action potentials
Term
deficiency in calcium
Definition
accelerated bone loss, tooth loss, muscle twithces, on edge feeling
Term
deficiency of calcium can be caused by
Definition
abnormal parathyroid function, vit D deficiency or low blood magnesium concentrations
Term
calcium and magnesium
Definition
should be taken together
Term
magnesium found in
Definition
leafy greens, nuts, grains, and milk
Term
functions of magnesium
Definition
energy production, cell signaling, synthesis of: DNA, carbs, lipids, glutethione, bone and cell membranes
Term
deficiency of mangnesium
Definition
'fingers on blackboard' nervous feeling, muscle spasms, anxiety, depression, insomnia
Term
68% of population is deficient in what micronutrient
Definition
magnesium
Term
correcting Mg deficiencies may increase lifespan by
Definition
stabilizing DNA and repairing cellular damage
Term
iodine found in
Definition
iodized salt, cod, fish, milk, seaweed, potato
Term
function of iodine
Definition
synthesis of thyroid hormones (T3, T4); T3 binds to thyroid receptors in cell nucleus to regulate gene expression
Term
deficiency in iodine
Definition
fatigue, weight gain, goiters, cretinism, death
Term
31.5% of children worldwide have what type of deficiency
Definition
iodine
Term
zinc is found in
Definition
red meat, oysters, crabs, yogurt, beans
Term
men need 2X more of what micronutrient than women
Definition
zinc
Term
functions of zinc
Definition
catalyzes over 100 enzymatic reactions, structural role in proteins, regulation role as gene transcription factor, role in cell signaling, regulates hormone release, nerve transmission
Term
deficiency in zinc
Definition
lack of sexual maturity and dwarfism in males, low testosterone, loss of taste
Term
40% of elderly are at risk of what micronutrient deficiency
Definition
Zinc
Term
Iron is found in
Definition
red meat, poultry, oysters, raisins, potatoes, legumes
Term
functions of iron
Definition
oxygen transport
Term
deficiency in iron
Definition
fatigue, anemia, inability to detox drugs, poor athletic performance, impaired thinking, cold all the time
Term
9-22% of teenagers and women are deficient in this micronutrient
Definition
iron
Term
iron is used in what enzyme
Definition
cytochrome p450 family that metabolizes and detoxifies drugs/ toxins
Term
cytochrome p450
Definition
family of enzymes that catalyzes reactions by using a heme iron to oxidize
Term
epigenetic changes can take
Definition
minutes to days
Term
only takes 4-6 weeks to change
Definition
digestive enzymes
Term
only 9 months to replace
Definition
almost all the cells in your body
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