Shared Flashcard Set

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Micro 12/10/12 Hepatitis Virus
HDPP final at UMMSM
24
Microbiology
Graduate
12/13/2012

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Cards

Term
Hepatitis A
Definition
Picornavirus with +RNA with VPg.
Term
Hepatitis B
Definition
Hepadnavirus with partially dsDNA
Term
Hepatitis C
Definition
Envelope flavivirus with +RNA transmitted parenterally and sexually or via infected needles
Term
Hepatitis D
Definition
Viroid-like agent transmitted through blood and sexual fluids.
Term
Hepatitis E
Definition
Calcivirus-like +RNA virus transmitted through fecal-oral route.
No vaccine available
Term
Hepatitis G
Definition
Flavivirus, enveloped +RNA
Term
Hepatitis A or E
Definition
Resistant to desiccation
Term
Hepatitis A
Definition
Fulminant type rare, 80% mortality.
Term
Hepatitis A
Definition
Elevates ALT and AST, causes jaundice (ictericia)
Term
Hepatitis A
Definition
Contagious before causing symptoms
High concentration in stool
Term
Hepatitis B, C
Definition
Transmitted via contaminated needles or sexual contact
Term
Hepatitis B
Definition
Infective particle is Dane particle
Term
Hepatitis B
Definition
S gene for envelope protein and C gene for capsid
Term
Hepatitis B
Definition
Surface antigen causes formation of immune complexes, and symptoms from cell-mediated immunity
Term
Hepatitis B
Definition
Envelope antigen is predictive of virulence
Term
Hepatitis B
Definition
Carrier state can allow virus to be shed for years if antibodies to envelope antigen do not develop
Term
Hepatitis B
Definition
Causes cancer by integrating into host DNA and activating cellular growth gene, which is also activated by liver regeneration due to cytotoxicity.
Term
Hepatitis B
Definition
Treatments are rarely effective, but vaccine is for 95%
Term
Hepatitis C
Definition
Cancer occurs by killing hepatocytes. Over-replication leads to carcinoma but it is not a retrovirus
Term
Hepatitis D
Definition
Only replicates in presence of HepB infection. Superinfection leads to rapid and severe symptoms
Term
Hepatitis D
Definition
Similar serologic course to HepB. Presence of HBsAg leads to fulminant hepatitis
Term
Hepatitis E
Definition
Asymptomatic or mild except in pregnant women
Term
Hepatitis E
Definition
Ingestion of contaminated food and water especially shellfish leads to disease
Term
Hepatitis G
Definition
Broad geographic distribution, spread through transfusions, needles, and sex.
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