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Metabolism
Energy and Enzymes
20
Biology
Undergraduate 2
10/13/2013

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Term
Thermal Energy
Definition
Heat; Kinetic energy associated with the random movement of atoms
Term
Kinetic Energy
Definition
Movement; the relative motion of objects
Term
Potential Energy
Definition
Energy that matter possesses based on location and structure
Term
Chemical Energy
Definition
Potential energy available for release in a chemical reaction
Term
First law of Thermodynamics
Definition
Energy cannot be created or destroyed, just transferred or transformed
Term
2nd law of Thermodynamics
Definition
During every transfer or transformation, some energy is lost as heat which contributes to the increase of entropy in the universe
Term
Free Energy
Definition
Can do work when temperature and pressure are uniform (potential energy, known as G)
Term
Entropy
Definition
Measure of disorder, randomness or chaos
Term
Endergonic vs. Exergonic
Definition
Endergonic: energy released, spontaneous, decrease in G
Exergonic: requires energy, non-spontaneous, increase in G
Term
Energy Coupling (within a metabolic pathway)
Definition
The use of an exergonic process to drive an endergonic one.
Term
How is ATP useful in energetic coupling?
Definition
Responsible for mediating most energy coupling in cells. Hydrolysis of ATP can be used to drive an endergonic reaction
Term
Activation Energy
Definition
Initial energy needed to start a chemical reaction (EA)
Term
Enzyme
Definition
Macromolecule that acts as a catalyst (lowers E subA).
Term
Substrate
Definition
The reactant and enzyme acts on.
Term
Active Site
Definition
Specific region of the enzyme which binds to a substrate (or substrates).
Term
Cofactor
Definition
Adjunct that is bound to an enzyme either permanently or loosely along with the substrate - performs a crucial chemical function in catalysis.
Term
Inhibitor (competitive and non-competitive)
Definition
Competitive: resemble a normal substrate molecule and compete for admission to the active site
Non-competitive (or allosteric): Impede enzymatic reactions by binding to another part and changing the enzyme shape
Term
Cooperativity
Definition
A kind of allosteric activation in which a substrate molecule binds to one active site in a multisubunit enzyme triggers a shape change in all subunits thereby increasing catalytic activity at other active sites.
Term
Feedback inhibition
Definition
A metabolic pathway is switched off by using it's end product as an allosteric inhibitor on an enzyme that acts early in the pathway
Term
How is ATP regenerated?
Definition
Exergonic processes in the cell are couple to regeneration of ATP (phosphorylation of ADP).
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