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Metabolism of Nutrients
Absorptive state metabolisms by Jo Woodnutt
18
Veterinary Medicine
Undergraduate 2
06/04/2012

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Term
What are the three possible routes for glucose metabolism in the absorptive state?
Definition
Glucose -> Direct utilisation by cells
Glucose -> Glycogen
Glucose -> Storage as TAG
Term
What is the main aim of glucose metabolism?
Definition
To preserve the blood glucose levels
Term
How many molecules of ATP are formed by the aerobic respiration of glucose?
Definition
38
Term
How many molecules of ATP are formed by the anaerobic respiration of glucose?
Definition
2
Term
Which enzyme catalyses the reaction from pyruvate to lactic acid?
Definition
Lactate dehydrogenase
Term
Which enzyme catalyses the reaction from pyruvate to Acetyl coA?
Definition
Pyruvate dehydrogenase
Term
How many ATP molecules can be formed by each NADH molecule?
Definition
3
Term
Describe how the electron transport chain forms ATP.
Definition
NADH -> NAD+ + H+. The H+ is pumped into the space between the inner and outer mitochondrial membranes, which creates a proton gradient.
H+ then diffuses back through the membrane through ATP synthase (the energy from the H+ is used to attach a Pi to ADP0
Term
What does the enzyme phosphoglucomutaste do?
Definition
Moves the phosphate group in glucose 6 phosphate from the 6 carbon to the 1 carbon forming glucose 1 phosphate
Term
Which enzyme catalyses the reaction from glucose 1 phosphate to UDP glucose?
Definition
UDPG phosphorylase
Term
What is the term for the formation of glycogen from glucose?
Definition
Glycogenesis
Term
What is the term for the formation of triacylglycerols from glucose?
Definition
Lipogenesis
Term
What does the enzyme acetyl coA carboxylase do?
Definition
Turns Acetyl co A into Malonyl co A
Term
How is palmitate formed in lipogenesis?
Definition
Acetyl co A primes the fatty acid synthase, then malonyl co A is taken up by the ACP part and adds 2C to the chain on the synthase part of the enzyme. This stage is repeated until the chain has 16C.
Term
What enzyme catalyses the reaction between palmitate and glycerol 3 phosphate and what is the product formed?
Definition
Acyl tranferase.

Palmitate + glycerol 3 phosphate = TAG
Term
How many ATP molecules are formed by acetic acid when it enters the TCA cycle?
Definition
10 ATP
Term
Describe how ruminants form glucose from VFAs.
Definition
2 propionate is changed to 2 succinyl co A in the liver. This is changed 2 phosphenolpyruvate and then to glucose.
Term
What are the VFAs absorbed by the ruminant?
Definition
Acetate, butyrate, propionate
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