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meiosis I and II
meiosis I and II
29
Biology
Undergraduate 1
10/23/2008

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Term
Meiosis I
Definition
Separates the two homologs1. Synapsis
Homologous chromosomes pair all along their lengths in prophase I
While paired homologs cross over

2. Reduction division
Homologs separate in Anaphase I reducing the chromosome number in 1/2 (2n to 1n)
This produces haploid gametes
Term
Zygote
Definition
Created by fertilization. Contains 2 copies of each chromosome
Term
Meiosis II
Definition
Separates the two sister chromatids
Term
Prophase I
Definition
Homologous chromosomes PAIR, cross over occurs (recombination of segments)
Term
Metaphase I
Definition
Homologous chromosome pairs LINE UP at random at the equatorial midline
Term
Anaphase I
Definition
Homologs SEPARATE and move to opposite poles
Term
Telophase I
Definition
Nuclear membrane reforms, chromosomes uncoil. After cytokinesis, two haploid cells are produced
Term
Meiosis II
Definition
After meiosis I there is a brief interphase
No DNA synthesis occurs

Meiosis II is similar to mitosis,
but with two main differences

1. Haploid set of chromosomes

2. Sister chromatids are not identical
because of cross over
Term
Prophase II
Definition
Begins with haploid cells
Spindle forms
Nuclear membrane breaks down
Each chromosome is composed of two sister chromatids attached at the centromere
Term
Metaphase II
Definition
Chromosomes line up on the midline and attach to spindle fibers
Term
Anaphase II
Definition
Centromeres divide

Sister chromatids move to opposite poles
Term
Telophase II
Definition
Nuclear membrane reforms,
Chromosomes uncoil. After Cytokinesis,
Four unique haploid cells are produced
Term
Sexual reproduction increases genetic diversity through three key mechanisms
Definition
1. Crossing over

2. Independent assortment

3. Random fertilization
Term
DNA exchanges between maternal and paternal chromatid pairs
Definition
DNA exchanges between maternal and paternal chromatid pairs
Term
Oncogene
Definition
Abnormal allele of a genes that causes cancer by influencing the cell cycle. Abnormal varients can encode the receptors that regulate growth and cell division.
Term
Tumor suppressor gene
Definition
Encode proteins that normally block cancer development; they promote normal cell death or prevent cell division
Term
Proto-oncogenes
Definition
Normal genes that stimulate cell growth/division. If mutated, they become oncogenes.
Term
p53 gene
Definition
plays a key role in the G1 checkpoint of cell division. the p53 protein, the gene's product, monitors the INTEGRITY OF DNA- can halt cell division and stimulate repair enzymes. a mutation of the p53 gene results in rapid dividing of cancer cells without the halt by the p53 protein.
Term
Which of the following is a difference between an autosome and a sex chromosome?
Definition
There are more autosomes than sex chromosomes in a cell.
Term
Why do homologous chromosomes have a similar appearance in a karyotype?
Definition
Because they share the same banding pattern,
Because they share the same amount of DNA
,Because their centromeres are in the same location
Term
Recombination is most likely to occur between
Definition
linked genes that are far apart
Term
What is the role of the Y chromosome in sex determination in humans?
Definition
It carries genes that control the formation of male body structures.
Term
What is the relationship between homologous chromosomes?
Definition
They carry different versions of the same genes.
Term
does independent assortment contribute to diversity?
Definition
no!
Term
what are some mechanisms that contribute to diversity?
Definition
Random fertilization,
Crossing over,
Cytokinesis
Term
an active site is the key to what?
Definition
Is a location on an enzyme, that is a key to the specificity of an enzymatic reaction
Term
substrate
Definition
The molecule (molecules) that fits into the active site of an enzyme and reacts with the enzyme
Term
cofactors
Definition
Substances needed by proteins in order to function as an enzyme,
Minerals,
Vitamins,
Must be provided to cells by the nutrients an organism takes in
Term
at chemical equilibrium, what is in balance?
Definition
reaction rates
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