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medicinal
test 3
6
Science
Post-Graduate
11/20/2008

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Term
H1 receptors mediate
Definition

Smooth muscle contraction,

increased vascular permeability;

 prostaglandin production;

pruritus-severe itching;

decreased atrioventricular conduction time;

 tachycardia;

 activation of vagal reflexesThr and Asn on transmembrane (TM) 5 bind the imidazole ring; electrostatic interaction between a-NH3+ and Asp on TM3.

Term
H2 receptors
Definition

 

acid-secreting cells mediate:

gastric acid secretion by gastric mucosa;

Asp on TM3 binds a-NH3+ of histamine.

Thr and Asp of TM5 bind to imidazole ring.

Term

H3 receptors

Definition
 

CNS autoreceptors.

 Regulate histamine synthesis and release.

 

Term

FIRST GENERATION H-1 ANTAGONIST

Definition
 
Aminoalkyl ethers 
Ethylenediamines
Piperazines
Propylamines
Phenothiazines
Dibenzocycloheptenes/heptanes
Term
Diphenhydramine Hydrochloride
Definition

(Benadryl):
Oily, lipid-soluble free base converted to stable, crystalline powder; pKa of 9.
Soluble in water, alcohol and chloroform.
Displays anticholinergic and sedative properties
Oral, IM and IV administration.

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