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medchem
test info
48
Medical
Graduate
12/02/2008

Additional Medical Flashcards

 


 

Cards

Term
clinical uses of PTH
Definition

osteroperosis: intermitant admin

 

Diagonsis of pseudohypothyroidism

Term
vitamin D deficiency
Definition

Rickets

osteomalacia

Term
insulin side effects
Definition

hypoglycemia

insulin allergies at injection site

insulin resistance

Term
calcitonin
Definition

lowers plasma CA++ levels

lowers plasma phosphosphate levels

Term
clinical uses of calcitonin
Definition

acute hypercalcemia

osteoperosis

Cushings disease

goiter

Term
Bisphosphonates MOA
Definition
directly inhibit bone resorption

inhibit osteoclasts
inhibit osteoperosis
have a high affinity for bone
Term
sypmtoms of hyperparathyroidism
Definition
hypercalcuria

hypercalcemia
kideny stones
skelatal abnormalities
muscle weakness
Term
vitamin D treatment for:
Definition

rickets

osteomalacia

hypocalcemia

hypoparathyroidism

kidney/renal disease (vitamin absorption impared)

Term
osteomalacia in children is called
Definition
rickets (vitamin D deficiency)
Term
estrogen activity in bone
Definition
decreases resoprtion

decreases osteoclast activity
Term
osteoperosis treatments
Definition

estrogens

androgens

bisphosponates (alendronate)

intermitant PTH

calcium + Vitamin D

Salmon calcitonin

Term
hyperthyroidism treatments
Definition

propylthiouracil (PTU)

methimazole (20X more potent than PTU)

lithium carbonate- inhibits thyroid

radioactive iodine- inhibits thyroid

Term
chronic overdose of T3 symptoms
Definition

increased BMR

heat intolerance excessive

sweating

weight loss

tachycardia

Term
methimazole (anti-thyroid) MOA:
Definition

inhibits thyroid synthesis

prevents conversion of T4 to T3

Term
what provides negative feedback to the secretion of ACTH by the pituitary?
Definition
cortisol
Term
cortisol effects(glucocorticoid)
Definition

immune suppression

 increased gastric acid production

increased Ca++ elimination (decreased plas level)

increased glucose plasma levels

inhibition of protein synthesis in muscle cells (opposite of androgens)

decreased plasma Ca++ levels

Term
glucocorticoids do what to plasma Ca++ levels?
Definition
decrease
Term
best treatment for hypothyroidism
Definition
sodium levothyroxine (T4) only converted to active T3 when needed
Term
chronic glucocorticoid administration can cause:
Definition

decreased muscle mass

hyperglycemia (gluco)

osteoperosis

decreased prostaglandin synthesis

slower wound healing

psychiatric disturbances, personality changes

Term
dexamethasone
Definition
potent glycocorticoid, little Na++ retention
Term
acute renal deficiency symptoms
Definition
addison's (JFK) hyperpigmentation
Term
anti-estrogene used for breast cancer
Definition
tamoxifen
Term
ketoconazole
Definition
steroid inhibitor and antifungal agent
Term
progestin + estrogen use:
Definition
to prevent breast and endometrial cancer
Term
progestins action
Definition

block ovulation

protect against cancerous effects of estrogen

Term
progesterone at time of ovulation causes:
Definition
increased body temperature
Term
treatments that stimulate GH release
Definition

amino acids

GHRH

Ghrelin

 

Term
tamoxifen
Definition

SERM used for breast cancer treatment

competative partial agonist inhibitor of estradiol at the estrogen receptor

Term
Gonadotropin side effects:
Definition

female infertility

multiple births

abortion

Male hypogonadism

Term
SERM MOA:
Definition

produce estrogen effects by binding to estrogen receptors

competative partial agonist inhibitor of estradiol at the estrogen receptor

Term
Bromocriptine (dopamine agonist)
Definition

works on D1 and D2

receptors supresses normal lactation

orally effective

Term
oxytocin side effects and contraindications
Definition

side effect: uterine rupture

contraindications: abnormal fetal position previous uterine surgery (weakened)

Term
anti-androgen theraputic uses
Definition

precocious puberty (early puberty_

hirsutism

acne

Prostatic cancer

Term
someone with hyperglycemia on insulin therapy could have side effects of:
Definition

dizziness

ketoacidosis

low blood glucose levels

Term
estrogen use in women:
Definition

menopausal symptoms

osteoperosis ovarian development

Term
adverse effects of estrogens
Definition

insulin antagonism

breast cancer

clotting disorders

Term
vasopressin Tannate causes
Definition

increased blood volume

decresed blood osmolarity

vasoconstriction

decreased urine volume

supression of endogenous vasopressin secretion

Term
hypercalcemia treatments
Definition

calcitonin

glucocorticoids

Term
what can supresss/effeect gonadotropins
Definition
GnRH agonists and antagonists
Term
clomiphene
Definition

SERM (anti-estrogen)

increases plasma GnRH levels

Term
NPH insulin
Definition

intermediate insulin (16-18hrs)

-can be combined with regular (short acting insulin)

Term
regular insulin
Definition

short acting insulin (3-4 hrs)

-can be combined with NPH (intermediate insulin)

Term
UL insulin
Definition
ultralente (long acting insulin) Glargine
Term
thyroidectomy/tetany treatment:
Definition

calcium salts: provide immediate action

calcium lactate

calcium gluconate

Term
alpha adrenergic blockers
Definition
used in BPH to help relax the muscles of the urinary tract
Term
frequent urination, increased thirst, increased fluid intake all of which developed slowly, are symptoms of
Definition
diabetes type 2
Term
primary diabetes type 2 treatment is
Definition
diet, excercise, and oral hypoglycemic
Term
what would suggest pituitary hypogonadism?
Definition
decreased FSH levels
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