immediate muscle fasciculations (waves of muscle contractions) lasting 1 minute

muscle relaxation for about 1 minute rapid recovery 5-10 minutes

hydrolyzed by plasma cholinesterases not acetylcholine esterase like Ach

uses: endotracheal intubation, brief procedures, electroconvulsive shock for depression

MOA: neuromuscular blockade to get tube in

low doses: effect PNS and decrease HR

high doses: can also activate the sypathetic ganglia which increases HR and BP

competative neuromuscular blocking drugs:

Curare properties (prototype)

(goals for curure based drugs)

onset and duration: 5 minutes; 1-2 hours -

causes ganglionic blockade leading to hypotension and tachycardia

-causes histamine release leading to hypotension and bronchiospasm

-metabolized in liver and eliminated via kidney

Pancurium properties

(unlike curare)

has a shorter onset and duration than pancurium

does not:

Block ganglionic nicotinic receptors

Stimulate histamine release

Block muscarinic receptor (unlike Pancuronium)

this is the best drug because it cant cause hypotension or tachycardia

CNS: Psycho Stimulant or Relaxant

cardiovascular: Small Increase in BP for brief periods  can cause atherosclerosis Increase in HR

 Gastrointestinal: PNS Nausea, Diarrhea, vomiting, salivation

Chantix It is a partial agonist

selective for  alpha4 beta2 nicotinic receptor

Stimulated dopamine release because this is the receptor present Partial agonist  binds to nicotinic receptor and produces some activation of the receptor (suppress cravings)

1) Parkinson's and Alzheimer's diseases

 2) cognitive performance

3) pain

4) schizophrenia