Use: Uterine stimulation, induce labor at term; prevention of hemorrhage; stimulation of milke let down reflex

PHK: IC, IM, nasal rout

Adverse: water intoxication, uterine rupture, anaphylaxis, sinus brady

Prostaglandin

Use: Uterine stimulation, expulsion of uterine contents in instances of intrauterine fetal death, missed abortion, elective abortion

Adverse: GI distrubances, vomiting, diarrhea

Other drugs: Carboprost Tromethamine (Prostin/M15®, Hemabate®)

Ergot Alkaloids

Use: Uterine stimulation, decrease uterine bleeding AFTER completion of labor and delivery

Mechanism: contraction of uterine smooth muscle through activation of serotonin and a-adrenergic receptors

Contraindications: don't use to induce labor (fetal hypoxia), hepatic or renal diseas

Other drugs: Methylergonovine Maleate (Methergine)

Use: Uterine Relaxation (tocolytic), prevent premature labor; may be given to pre-eclamptic pts to prevent convulsions or as tx for exlamptic pts

Not FDA approved; 1st line though

Use: Uterine relaxation (tocolytic agent), prevent premature labor

Mechanism: Ca channel blocker

Not FDA approved; Starting to be 1st line though

Use: Uterine relaxation (tocolytic agent), prevent premature labor

Mechanism: Reduction of prostaglandin synthesis (prostaglandins = uterine contraction)

Adverse: partial closure of fetal ductus arteriosus

Not FDA approved

Use: Uterine relaxation (tocolytic agent), prevent premature labor; prophylactic (16th to 37th week of pregnancy); NOT EFFECTIVE ACUTELY

NOT FDA approved

Use: Uterine relaxant (tocolytic agent), prevent premature labor

Mechanism: Direct relaxant effect on myometrium and inhibition of oxytocin release

Not FDA approved