Term
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Definition
stomach pH: 2-6
Intestine pH: 6-8 |
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Term
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Definition
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Term
|
Definition
less than 4 angstroms
less than 200 molecular weight |
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Term
| Log S is the solubility in water |
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Definition
| Log S greater than -4 is soluble in water |
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Term
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Definition
| SOLUTE CARRIER PROTEIND (UPTAKE AND EFFLUX) |
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Term
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Definition
| ATP BINDING CASSETTE PROTEINS(efflux) |
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Term
|
Definition
OAT [ORGANIC ANION TRANSPORTER]
OATP [ORGANIC ANION TRANSPORTER PROTEIN]
OCT[ORGANIC CATION TRANSPORTERS]
MATE [MULTIDRUG AND TOXIN EXTRUSION] |
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Term
|
Definition
ON APICAL SIDE OF ENTEROCYTE
[INHIBITOR: GRAPEFRUIT,Ornge juice]
[SUBSTRATE: FEXOFENADINE] |
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Term
|
Definition
IN KIDNEY TUBULES
UPTAKE OF GLYCINE CONJUGATES FROM BLOOD INTO KIDNEY
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Term
|
Definition
PROBENECID
[OAT1 Substrate: P-aminohippurate] |
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Term
| OCT (ORGANIC CATION TRANSPORTER)[WHERE FIND] |
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Definition
TAKES UP DRUG FROM BLOOD INTO HEPATOCYTE(LIVER)
[Substrate: METFORMIN]
[Inhibitor: Cimetidine] |
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Term
|
Definition
LIVER AND KIDNEY
TAKES CATIONS OUT[EFFLUX]
SLC
[from hepatocyte to bile, kidney to urine]
ex:metformin |
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Term
|
Definition
CIMETIDINE
[also an OCT inhibitor] |
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Term
|
Definition
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Term
|
Definition
CANCER CELLS
[TOO MUCH EFFLUX PROTEIN CAUSES MULTI DRUG RESISTANCE] |
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Term
| MDR1 (MULTI DRUG RESISTANCE PROTEIN 1) |
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Definition
AKA p glycoprotein[usually passive lipophilic dif]
EFFLUX PROTEIN
(IN INTESTINE)
LIMITS DRUG ABSORPTION IN ENTEROCYTES |
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Term
| MDR1 RECOGNIZES______ AND _____ DRUGS |
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Definition
NEUTRAL AND WEAKLY CATIONIC
[SUBSTRATES ARE BULKY] |
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Term
MDR1 SUBSTRATES
(BULKY ISH) |
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Definition
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Term
|
Definition
VERAPAMIL
[USUALLY USED AS A TEST TO SEE WHATOTHER DRUGS BIN P GLYCOPROTEIN] |
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Term
| ANION EFFLUX PROTEINS (2) |
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Definition
MRP2 =MULTI DRUG RESISTANT PROTEIN 2
BCRP= BREAST CANCER RESISTANT PROTEIN |
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Term
mrp2 (MULTI-DRUG RESISTANCE PROTEIN 2)
(FOUND WHERE) |
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Definition
LIVER, BRAIN, INTESTINE,KIDNEY (*bilk mneumonic)
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Term
mrp2 (MULTI-DRUG RESISTANCE PROTEIN 2)
SUBSTRATES<< |
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Definition
INDINAVIR
CISPLATIN
ACETAMINOPHEN GLUCURONIDE |
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Term
bcrp (BREAST CANCER RESISTANCE PROTEIN)
FOUIND WHERE????(*PILB mnuemonic) |
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Definition
PLACENTA
INTESTINE
LIVER
BREAST |
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Term
bcrp (BREAST CANCER RESISTANCE PROTEIN)
SUBSTRATES......
effluxed several cancer drugs(first found in mdr breast cancer cells) |
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Definition
estrone sulfate
methotrexate |
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Term
|
Definition
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Term
|
Definition
OAT
OATP
OCT
MATE(EFFLUX) |
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Term
|
Definition
JANITOR (*mops p MNEUMONIC)
Morphine
Ondansetron
Prednisone
Simvastatin
Pentobarbital (most of barbiturates) |
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Term
| UPTAKE transporters (*OOO mnuemonic) |
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Definition
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Term
Paracellular drugs (water soluble)
(MAA*) |
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Definition
Metfromin
Acetaminophen
Aspirin |
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Term
| Efflux Transporters(MMMB*) |
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Definition
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