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MCB 63 midterm
Nervous System Development
30
Biology
Not Applicable
07/20/2007

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Term
blastocyst
Definition
fertilized structure – sphere of cells filled with fluid
Term
Describe the three germ layers
Definition
i. Endoderm (internal organs)
ii. Mesoderm (bone, structural components – connective tissue, etc.)
iii. Ectoderm (skin, nervous system)
Term
notochord
Definition
•Group of cells develop inside the mesoderm
•stimulates growth of CNS, remains in between vertebrae
Term
Describe the developmental impact of the notochord
Definition
•As the notochord secretes hormones, it stimulates cell growth in the ectoderm, forming the neural crest
•Cell growth pushes two crests together until they begin to seal over -> forms the neural tube
•Neural tube starts to seal in the middle and moves outwards
Term
Anterior neuropore
Definition
•Neuropores are the last things to seal up -> usually seal ~ 6 weeks into pregnancy
•Anterior neuropore should seal over first (anterior components of the nervous system develop more quickly
•If the anterior neuropore does not seal, the brain does not form (ex. Child is born with anencephaly – missing cerebral cortex, part of the skull and scalp
Term
endoderm
Definition
future internal organs
Term
mesoderm
Definition
future structural components (bone, connective tissue, etc.
Term
ectoderm
Definition
future skin and nervous system
Term
spina bifida
Definition
deformity of the lower spinal cord, caused when the posterior neuropore does not seal
Term
anencephaly
Definition
cerebral cortex, covering skull and skin do not form; caused when the anterior neuropore does not seal
Term
myelencephalon
Definition
secondary brain vesicle; future medulla oblongata
Term
metencephalon
Definition
cerebellum and pons
Term
mesencephalon
Definition
midbrain (includes superior and inferior colliculi
Term
diencephalon
Definition
thalamus and hypothalamus
Term
Thalamus
Definition
• Thalamus is involved in integration and processing sensory input (except smell)
Term
Hypothalamus
Definition
• Hypothalamus controls the endocrine system (reproductive functions, etc.), the autonomic/visceral nervous system (respiratory and heart rate, appetite, etc.)
Term
telencephalon
Definition
cerebral cortex, hippocampus, basal ganglia
• Telencephalon has the largest growth
• First grows downwards, than in other directions as it pushes on the cranial vault
• Runs out of space -> tissue begins to fold and curl in a circular fashion
• All structures from the telencephalon have a circular structure
Term
Basal Ganglia
Definition
Basal Ganglia now called basal nuclei, are involved in fine motor coordination (works with cerebellum, thalamus, and colliculi), emotional response, learning
Term
Diseases of basal ganglia
Definition
tremors, involuntary movements (Parkinson’s, Tourette’s)
Term
Spinal cord growth
Definition
The Spinal cord stops growing before the rest of the body -> the spinal cord does not extend the full length of the vertebral column.
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What are the primary brain vessicles?
Definition
Prosencephalon, Mesencephalon, Rhombencephalon
Term
What are the five secondary brain vessicles?
Definition
Telencephalon, Diencephalon, Metencephalon, Mesencephalon, Myelencephalon
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