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MBIOS exam #2
microbiology
54
Biology
Undergraduate 2
03/07/2009

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Term
commensalism
Definition
benefits one, other doesn't care (skin)
Term
mutualism
Definition
have to have
Term
parasitism
Definition
host is harmed, organism benefits
Term
ectopic host
Definition
wrong host
Term
Exotoxin
Definition
proteins secreted out of organism --> very specific to organs
Term
Neurotoxins
Cytotoxins
entertoxins
Definition
nerves
cells
secretion -> GI tract
Term
Endotoxins
Definition
LPS Layer (gram -)
designed to have a full body shut down
as organism is destroyed, it releases harmful toxins
Term
Toxicity
Definition
Exo: toxic in minutes
Endo: toxic in high doses
Term
Effects on the body
Definition
Exo: specific to a cell type (blood,liver, nerves)
Endo: Systemic: fever, inflammation, whole body shut down
Term
Chemical Composition
Definition
Exo: small proteins
Endo: LPS of cell wall (gram -)
Term
Heat Denatured at 60 degrees C
Definition
Exo: YES!
Endo: NO
Term
Toxoid Formation
Definition
Exo: Can be comverted to toxoid (vaccine)
Endo: cannot be converted to toxoid (no vaccine)
Term
Immune Response
Definition

Exo: yes: stimulates antitoxins

Endo: no: doesnt stimulate antitoxins

Term
Fever Stimulation
Definition

Exo: Usually not

Endo: Yes-classic sign of full body shut down

Term
Manner of release
Definition

Exo: Secreted from live cell

Endo: Released by cell via shredding or during lysis

Term
Typical Sources
Definition

Exo: few gram+ and gram-

Endo: All gram- bc LPS layer

Term
Chemotherapeutic Drug
Definition
Any chemical used in the treatment, relief, or prophylaxis of a disease.
Term
Prophylaxis
Definition
use of drug to PREVENT imminent infection of a person at risk
Term
Antimicrobial Chemotherapy
Definition
The use of chemotherapeutic drugs to CONTROL INFECTION
Term
Antimicrobials
Definition
term for any antimicrobial drug, regardless of its origin
Term
Antibiotics
Definition
substances produced by the natural metabolic processes of some m.organisms that can INHIBIT or DESTROY other m.organisms
Term
semisynthetic drugs
Definition
natural drugs that were chemically modified
Term
Synthetic drugs
Definition
drugs made with chemicals only in a lab
Term
narrow spectrum
Definition
targeting certain organisms, effective mainly on gram+ bacteria
Term
broad spectrum
Definition
gram+ and gram- bacteria works on a wide variety
Term
pasteurization
Definition
use of heat to eliminate organisms in solutions
Term
sterilization
Definition
kill/destroy all microbial life
Term
decontamination
Definition
reduce organism on inanimate objects to safe levels
Term
antisepsis
Definition
kill/destroy organism on body surface/skin
Term
Coagulase
Definition
forms blood clots
Term
protease
Definition
dissolves proteins/muscle
Term
necrotizing factor
Definition
death of body cells/cell death
Term
collagenase
Definition
dissolves connective tissue
Term
lecithinase
Definition
destroys cell membranes
Term
hemolysins
Definition
lyses red blood cells
Term
hypothermic factor
Definition
decreases body temp
Term
leukocidins
Definition
destroys white blood cells
Term
mucinase
Definition
dissolves mucus
Term
bacterial kinase
Definition
dissolves blood clots
Term
3 mechanisms organisms use to Avoid the defenses or immune response of host cells
Definition

1. Avoid phagocytosis--dont allow to be eatten by using the actin tail to attach to the microorganims 2. get eatten--do this by hiding in the White blood cells

3. change outer appearance--host cell will not be able to recognize or identify organism

Term
3 ways to "side step", prevent the drug/antibiotic from killing organism
Definition

1. Make enzymes to destroy the drug

2. Change membrane receptors making it so the drug cannot attach to the microbe

3. Pumps can be used to pump drug in then right back out

Term
4 factors to consider when choosing a chemical control method
Definition

1. temp and pH

2. the # of microorganisms

3. concentration of agent

 4. how the chemical agent works

Term
Transmission: Oral-Fecal
Definition

Personal contact, food, water

ex: salmonella and e.coli

Term
Transmission:
Blood and wounds
Definition
injection drug use, injuries, surgeries, needle pricks, transfusions
ex: AIDS and hepatitis B
Term
Transmission: sexual transmissions
Definition

genital-genital

genital-oral

genital-anal

ex: HIV and herpes

Term
2 Neurotoxins
Definition

clostrinium tetani--whole body spasms

clostrinium botulism--flaccid paralysis

Term
2 other toxins
Definition
staphylococcus aureus--wounds
escherichia coli--diarrhea
Term
3 cytotoxins
Definition
amanita phalloides--GI tract problems
Streptococcus pyogenes--scarlet fever/red rash
Term
Chemical agents
Definition

phenol--denatures proteins

hydrogen peroxide--cleans wounds

chlorine--kills pathogens in water

Term
physical agents
Definition

pasturization--decreases # of heat sensitive microorganisms

autoclaving--destroys endospores, sterilizes ojects(lab glassware)

Incineration--oxidizes cell components with flaming

Term
mechanical agents
Definition

filteration of liquid--(pore size)used to make beer and wine

filteration of air--HEPA filters

Term
reservoir
Definition
environment when a microorganism lives and allows for it to replicate or maintain
Term
biological vector
Definition

actively participating in a pathogens life cycle, serving as a site for multiplication and completing the life cycle

ex: mosquito carrying malaria

Term
mechanical vector
Definition

an animal that transports an infectious agent, but is not personally affected by it.

ex: housefly whose feet have been contaminated with feces

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