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MBG 2400 LEE Intro Lecture & Concept #1
mendelian genetics, genetic variation, epistasis, ratios, mitosis/meiosis, recombination
42
Biology
Undergraduate 2
10/14/2013

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Term
Define genotype
Definition
Genetic constitution of an individual in terms of alleles at a specific gene/across a series of genes
Term
Define phenotype
Definition
The observable characteristics as defined by the genetic information of the genotype
Term
What term describes "heritable differences in genome constitution that result in observable differences in phenotype"
Definition
Genetic variation
Term
What is the "central dogma"
Definition
DNA -> RNA -> Protein
Term
What is a gene?
Definition
Segment of DNA that is transcribed into mRNA then translated into a protein
Term
What is an allele?
Definition
Alternate forms of a gene that give rise to distinct phenotypes
Term
What is Mendel's 1st Law
Definition
Units factor in pairs (2 possible alleles at any given gene)
Term
Mendel's 2nd Law?
Definition
Dominance/recessiveness
Term
Mendel's 3rd Law?
Definition
Segregation
-alleles are transmitted independently of one another from parent to gamete, each gamete having either one or hte other
Term
Mendel's 4th Law?
Definition
Independent Assortment
-alleles are transmitted indpendently of one another from parent to offspring, and there are various possible combinations
Term
What is the exception to independent assortment?
Definition
Linked genes.
Linked genes are on the same chromosome, and close enough together that the probability of crossing over occuring is <1.
Term
What are the 2 possible causes of independent assortment?
Definition
-genes are on separate chromosomes
-genes are on the same chromosome but far enough apart that the probability of crossing over is 1
Term
T or F
Plants have genes in 3 locations, animals in just 2.
Definition
True
Term
Define epistasis
Definition
Different phenotypes resulting from interactions between 2 genes
Term
What is a 9:4:3 epistatic ratio?
Definition
Complete dominance, recessive epistasis. When one gene is homo recessive it masks the effect of the other
Term
12:3:1 ratio?
Definition
when one gene is dominant, the phenotype of the other is hidden.
e.g. 1 class: A-B- or A-bb
2nd class: aaB-
3rd class: aabb
Term
15:1 ratio?
Definition
If a gene is dominant, the effects of the other alleles are hidden
e.g. one class is Aab/AaBbaaBb, the other is aabb
Term
What is the only mechanism that shuffles genetic variation?
Definition
recombination
Term
True or False
Chromosomes contain all 'Mendelian' genes
Definition
True
Term
True or False
Chromosomes contain most but not all DNA in a cell
Definition
True
Term
How can you identify specific chromosomes in a species?
Definition
Using the arm ratio of short arm:long arm
Term
Why is crossing over important?
Definition
It allows different allelic combinations to occur between linked genes
It creates novel variation
Term
What stage of meiosis is the reduction division?
Definition
Meiosis 1
Term
Why is the reduction division important?
Definition
Would have offspring with twice the # of chromosomes if reduction didn't occur
Term
When does crossing over occur?
Definition
Meiosis 1
Term
What stage of meiosis does the following occur in?
"Homologous chromosomes pair, forming bivalents at the metaphase plate"
Definition
Meiosis 1
Term
When do sister chromatids separate
Definition
Meiosis 2
Term
What is aneuploidy
Definition
When an organism has either 1 extra or 1 fewer chromosomes than normal
Term
What is euploidy
Definition
When an entire chromosomal set deviates from the 2x condition
Term
If an organisim has multiple sets of chromosomes from 1 ancestral origin, what is it called?
Definition
Autoploid
Term
If an organism has multiple sets of chromosomes from different ancestors, what is it called
Definition
Alloploid
Term
True or False
Triploids are usually sterile
Definition
True
Term
What is translocation?
Definition
The physical exchange of genetic material between different chromosomes
Term
What is a terminal deletion?
Definition
Just one segment of 1 chromosome is broken off
Term
If terminal deletion occurs in meiosis, what will happen?
Definition
The gametes will be haploid, and be missing the 'genes' that were broken off. Will probably be aborted/absorbed
Term
What is paracentric inversion in symmetrical form? Are two breaks required for this or one?
Definition
If a piece is broken off, then flipped around and re-attached to the chromosome
Two breaks
Term
What are the products of paracentric inversion - asymmetic form?
Definition
An acentric ring (consisting of the broken off piece of DNA) and DNA segement with interstitial deletion.
Term
T or F
The more chromosomes involved, the more possible combinations of assortment can occur
Definition
True
Term
Define hemizygous
Definition
Missing one allele
Term
What are the products of pericentric inversion - asymmetrical form? Are two breaks required for this or one?
Definition
A centric ring (the original portion of DNA) and an acentric fragment.
Two breaks
Term
What happens to a DNA fragment (that doesn't have a centromere) during meiosis?
Definition
They are lost (spindle fibres can't attach)
Term
What did the Creighton & McClintock paper illustrate?
Definition
Physical exchange of genetic information between homologous chromosomes in maize. Recombination!
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