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MBG 2400 LEE Concept #5 GENOME STRUCTURE
synteny, diagrams, genome structure, gene order
17
Biology
Undergraduate 2
10/16/2013

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Term
What did Hugo Dooner study?
Definition
the maize genome
Term
What is synteny?
Definition
A DNA sequence that prevails between members of the same order/gamily/genus
Term
The more ______ the ancestral relationship, the higher the degree of conservation
Definition
recent
Term
A highly conserved gene (traces far back in evolutionary history) is likely (essential/nonessential) for function
Definition
essential
Term
What is a gene island?
Definition
3-4 genes surrounded by long stretches of repetitive DNA
Term
What are long-range control elements (LRCE)?
Definition
unique sequences, function is unknown but thought to control/effect phenotypic expression indirectly
Term
What 4 prevailing thoughts did the Fu & Dooner paper disprove?
Definition
-repetitive DNA is not highly important
-SNPs are very common, major source of genetic variation
-sequence variation is less common
-loss of gene order within a species is almost non-existant
Term
What is 'sequencing'
Definition
To determine the base pair order along a sequence of DNA
Term
What is the difference in gene content between two individuals?
Definition
Copy number variation
Term
How often do crossover events occur in corn?
Definition
-once per chromosome arm (2x/chromosome)
Term
True or False
crossover in pigs occurs more often in females than in males
Definition
true
Term
True or False
the less homology there is between chromosomes, the more recombination occcurs
Definition
false

MORE homology = more recombination
Term
Does recombination occur in hemizygous or methylated regions?
Definition
no
Term
What is the 'wobble' position
Definition
The 3rd nucleotide in a codon
Term
What is the effect of a SNP in the 'wobble' position?
Definition
Potentially might not change the amino acid that is being coded for
Term
Where is genetic material found?
Definition
In the nucleus (chromosomes)
In mitochondria (cytoplasm)
Term
How is genome size measured?
Definition
In # of doouble stranded base pairs
OR
the mass (in picograms) of 1 copy of the genome
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