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Mammary Physiology Exam 1
Mammary Physiology Evolution through Involution
59
Biology
Undergraduate 4
02/13/2016

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Term
Apocrine Secretion
Definition
Sweat glands and the mammary gland. Only a portion of cells are lost so that individual cells survive and are capable for periodic secretion
Term
Holocine secretion
Definition
Sebaceous glands. Cells are ruptured and sloughed to become a part of the secretion.
Term
Merocrine secretion
Definition
Mammary gland. Products secreted but the secretory cells remain intact.
Protein and lactose packaging.
Term
What type of secretion is milk secretion?
Definition
Apocrine. Fat droplets in the cytoplasm migrate and are pinched off.
Term
Non-nutrient secretions
Definition
Lactoferrin, lysozyme, lactoperoxidase, immunoglobins, casin, and alpha-lactoblumin.
Term
Nutrient secretions
Definition
carbohydrate: lactose
Protein: Casin, alpha-lactalbumin, beta-lactalbumin
Lipids, minerals, and vitamins.
Term
Main support for the Udder
Definition
Deep lateral suspensory ligament, and the median suspensory ligament.
Term
Superficial lateral suspensory ligament
Definition
Very fibrous with elastic tissue
Term
Deep lateral suspensory ligament
Definition
fibrous, extends under enveloping udder.
Term
Lateral suspensory ligament
Definition
Substantial support. Doesn't stretch. Udder when full will pull away from the body.
Term
Median suspensory ligament
Definition
Arises from abdominal wall. Dives udder into 4ths. Can stretch
Term
Milk ejection hormone
Definition
Oxytocin
Term
Lymph
Definition
Clear colorless liquid with a composition similar to blood plasma
Term
Parenchymal tissue
Definition
Epithelium secretory tissue. Alveoli
Term
Lobules make up
Definition
Lobes
Term
Ducts are ___
Ductules are ___
Definition
Large
Small
Term
Alveoli function
Definition
Milk synthesis and secretion. Holds 1/5 of a drop.
Term
Basal is...
Apical is...
Definition
Blood side
Exposed to alveolar lumen
Term
Stroma is...
Definition
connective/supportive tissue.
Term
Alveoli are made up of what kind of cells?
Definition
Myoepithelial
Term
What happens to alveoli during dry period?
Definition
Cells loose structure and are reabsorbed.
Term
During parturition the number of mitochondria
Definition
Increases
Term
Endoplasmic reticulum
Definition
Site of lipid synthesis.
Term
Rough ER
Definition
Milk protein synthesis
Term
Smooth ER
Definition
Transport of materials
Term
Golgi
Definition
Grows larger during lactogenesis. Lactose synthesis. Final packaging of milk proteins.
Term
Secretory vesicles
Definition
Carry non-fat constituents and vesicular membranes to apical membrane
Term
Lysosomes
Definition
Degrade unwanted shit
Term
Cytoplasm
Definition
Macromolecules and nutrients. Site of anaerobic break down of glucose
Term
Tight junctions...
Definition
Stop passage of materials
Term
Gap junctions
Definition
allow low molecular weight molecules to move between cells
Term
5 routes to enter milk
Definition
Uptake of amino acids, sugars, milk fat precursors, preformed proteins, and paracellular pathway.
Term
What are the two phases of secretory activities?
Definition
1) formation of intracellular secretory structures
2) release of products into lumen. Cells become cubodial.
Term
Factors that effect production
Definition
Ability of gland to produce, number of cells, diet, stress, age, health, breed...
Term
Mammogenesis
Definition
Before lactation, growth and development of gland
Term
Lactogenesis
Definition
Pregnancy initiation of milk secretion
Term
Galactopoeisis
Definition
Maintenance of milk secretion/ actual lactation
Term
Proliferation
Definition
cell multiplication
Term
Differentiation
Definition
Cells become more specialized
Term
Endocrine signals
Definition
secreted into the blood
Term
Autocrine
Definition
targets sites on same cell
Term
Paracrine
Definition
one cell affects another
Term
Intracrine
Definition
In the cell.
Term
Steroid hormones
Definition
Estrogen, progesterone, and cortisol.
Term
Protein hormones
Definition
Growth hormone, prolactin, insulin, IGF-1, Follicle Stimulation Hormone, and LH
Term
Isometric growth
Definition
growth that occurs at the same rate as the body
Term
Allometric growth
Definition
growth that doesn't occur at the same rate as the body
Term
At birth the mammary gland...
Definition
isn't developed. The teats and the nonsecretory tissue are.
Term
Mammary parenchymal growth is rapid...
Definition
Before puberty, around conception, and lactogenesis.
Term
Major regulators of mammary development
Definition
Estrogen (E2), Prolactin, IGF-1, Progesterone (P4), somatotropin (growth hormone), and glucocortcoids.
Term
Estrogen
Definition
ovarian hormone. Stimulates growth of ducts.
Requires: prolactin and somatropin
Term
Progesterone
Definition
ovarian hormone. Initiates multiplication of ducts and ductle cells. Leads to duct development.
Term
Growth/somatotropin hormone
Definition
Pituitary hormone. Stimulates mammary growth. Increases synthesis of IGF-1.
Term
Prolactin
Definition
Stimulates ductal branching, and lobular-alveolar development.
Term
IGF-1
EGF
FGF
Definition
Promotes alveolar epithelial cell growth.
Epithelial cell growth
Increases growth of alveolar cells blocks differentiation.
Term
Lactation begins fully when
Definition
progesterone declines.
Term
Hormone concentration around parturition
Definition
Progesterone low, glucocorticoids high, estrogen high, and prolactin high.
Term
ACTH is from the
Definition
Pituitary. Works with cortisol
Term
Cortisol is from
Definition
adrenal. Works with ACTH
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