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Macrolides
Macrolides
13
Pharmacology
Professional
08/19/2012

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Cards

Term
MOA of macrolides
Definition

binds to the 50s ribosomal subunit, resulting in inhibition of RNA protein synthesis.

Term
Name the macrolides
Definition

Azithromycin (Zitromax, Z-Pak)

Clarithromycin (Biaxin, Biaxin XL)

Erythromycin (E.E.X., Ery-tab)

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Term
Brand name of Azithromycin
Definition
Zithromax, Z-Pak
Term
Brand name for Clarithromycin
Definition
Biaxin, Biaxin XL
Term
Brand name for Erythromycin
Definition
E.E.X,. Ery-tab
Term
Desribe antibiotic activity of Macrolides
Definition
activity against gram (+), some gram (-) and good atypical coverage.
Term
Which macrolide is used in the treatment of Gonorrhea?
Definition

Azithromycin

 

Term
Can macrolides be used in PCN allergic patients?
Definition
Yes!
Term
Should azithromycin oral suspension (Zmax) be refrigerated?
Definition
No!
Term
Storage and administration of Biaxin oral suspension.
Definition

Take Biaxin XL with food. Do not refrigerate Biaxin oral suspension.

Term
Storage instructions for erythromycin.
Definition

Must refrigerate erythromycin ethylsuccinate (E.E.S.) oral suspension.

Term
Is ER suspension (Zmax) bioequivalent with Zithromax?
Definition
No!
Term
Which of the two macrolides are major 3A4 inhibitors?
Definition

Erythromycin and Clarithromyci

 

Note: do not concurrently use agents that can prolong the Q-T interval with erythromycin and clarithromycin.

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