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Mac 2
Cephalic, Oral & Esophageal Phases of a response to a meal
33
Physiology
Undergraduate 2
04/10/2012

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Term
Stimulus for Cephalic Phase
Definition
Cognitive: Auditory, olfactory, visual.
Term
Pavlov's experiment
Definition
Pairing auditory stimulus to presentation of food; auditory stimulus alone-salivary secretion. Dog's were given food along with the ring of a bell. When bell is rung later, even with now food, the dogs would salivate.
Term
Purpose of the cephalic phase
Definition
Prime the system for the ingestion of food.
Term
What part of the brainstem is activated by cephalic stimulus?
Definition
The dorsal motor nucleus.
Term
Dorsal motor nucleus causes what effects in the body?
Definition
Salivary secretion, gastric acid secretion, pancreatic juice secretion, gall bladder contraction, and relaxation of the sphincter of Oddi.
Term
What nerve connects the dorsal motor nucleus to the abdominal digestive system?
Definition
The vagus nerve.
Term
What nerve connects the dorsal motor nucleus to the salivary glands?
Definition
Cranial nerve 9
Term
What are the three salivary glands?
Definition
Parotid, sublingual, and submandibular.
Term
What type of cell secretes the proteins in a salivary gland?
Definition
Salivary acinar cells.
Term
What cells are responsible for secreting fluid, potassium, and bicarbonate in salivary glands?
Definition
Cells lining the salivary duct.
Term
Percentage composition of salivary fluid.
Definition
99.5% H2O
0.5% proteins and electrolytes
Term
Composition of salivary proteins, and function of each.
Definition
Salivary amylase - breakdown of carbohydrates
Mucin - mix with H2O to lubricate
Lysozyme - antibacterial
Lipase - begin breakdown of lipids
Term
Initial tonicity of salivary fluid (relative to blood)
Definition
Hypotonic due to a lack of sodium
Term
Tonicity of salivary fluid after a high flow rate (relative to blood)
Definition
Isotonic due to a leveling out of sodium
Term
On top of lysozyme what also makes salivary fluid antibacterial?
Definition
High levels of bicarbonate create alkaline conditions which are detrimental to bacteria.
Term
What is found on the basilar membrane of salivary acinar cells?
Definition
Sodium-potassium ATPases, potassium channels, sodium-hydrogen antiports, and a sodium-chloride-potassium cotransport.
Term
What is found on the apical membrane of salivary acinar cells?
Definition
Potassium channels, and chloride-bicarbonate channels.
Term
What allows sodium to follow the flow of bicarbonate through the salivary acinar cells?
Definition
Leaky junctions between adjacent cells permit the movement of sodium.
Term
Receptors exist on the basal side of salivary acinar cells for what two transmitters?
Definition
Ach and VIP
Term
Activation of the Ach receptor on the basal membrane of salivary acinar cells causes what affect within the cell?
Definition
An increase in intracellular calcium which will cause activation of the apical channels.
Term
What exists on the apical membrane of the salivary acinar cells to allow movement of water?
Definition
Aquaporin 5 water channels.
Term
What directly stimulates bicarbonate secretion in salivary acinar cells?
Definition
Hormonal stimulus.
Term
How long does it take a salivary gland to product their own weight in fluid?
Definition
One minute.
Term
What type of reflex is the salivary response to cognitive stimulus?
Definition
A conditioned reflex.
Term
What is the most complex reflex in the body?
Definition
Swallowing!
Term
Can you stop swallowing halfway?
Definition
No. It is an all-or-none reflex.
Term
What is the initial step in the swallowing reflex?
Definition
The tongue is thrust up and back.
Term
What term is used to describe food that has been chewed up?
Definition
A bolus.
Term
How long does the pharyngeal phase of swallowing last?
Definition
Less than one second.
Term
What protects the pharynx from the bolus as the esophagus moves it downward?
Definition
Closing of the upper esophageal sphincter.
Term
What protects the esophagus from the gastric juices?
Definition
Closing of the lower esophageal sphincter.
Term
What structure stops a bolus from entering the trachea?
Definition
The lowering of the epiglottis blocks the entrance to the trachea.
Term
What moves a bolus from the top to bottom of the esophagus?
Definition
Peristaltic contractions of the esophagus act to move a bolus downward.
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