Term
| Signs and symptoms of Hodgkin's Disease |
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Definition
| Lymphadenopathy above the diaphragm, NO-involvement of Waldeyer's ring, and "B symptoms" |
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|
Term
| What cells must be Identified in Hodgkin's Disease and what marker must be present? |
|
Definition
| Reed-Sternberg cells (large bi-nucleated cell); CD30+ |
|
|
Term
| What type of cells are diagnostic of Nodular Sclerosing type Hodgkin's Disease? |
|
Definition
| Lacunar variant Reed-Sternberg cells |
|
|
Term
| What are PET scans used for when diagnosing Lymphoma? |
|
Definition
| Presence of the disease (by measuring metabolic activity) rather than size |
|
|
Term
| A normal PET scan after 2 cycles of chemotherapy is indicative of what? |
|
Definition
| A good pronosis (the opposite is true for an abnormal PET scan) |
|
|
Term
| How does Brentuximab Vedotin work and what is it supposed to treat? |
|
Definition
| Binds to CD30 and is effective against >50% of resistant Hodgkin's Disease |
|
|
Term
| What is the treatment for Diffuse Large B cell NHL? |
|
Definition
| Chemotherapy including Rituximab |
|
|
Term
| What is the action of Rituximab? |
|
Definition
|
|
Term
| What can be used to treat individuals who relapse with Diffuse large B cell NHL? |
|
Definition
| High-Dose Chemo and Autologous Stem cell transplant |
|
|
Term
| Is Follicular B-Cell lymphoma treatable? |
|
Definition
| Yes, but not curable. Most patients aren't affected much anyway |
|
|
Term
| A t(14;18) translocation associated with Follicular B-Cell lymphoma gives what property to the lymphoma? |
|
Definition
| Anti-Apoptotic effect due to overexpression of bcl-2 |
|
|
Term
| When should you perform Radiation therapy of NHL? |
|
Definition
|
|
Term
| Pautrier's Abscess and "Cerebriform Nuclei" are indicative of what disorder? |
|
Definition
|
|
Term
| What is the most common form of Cutaneous T-Cell lymphoma? |
|
Definition
|
|
Term
| Early stage Cutaneous T-Cell lymphoma can be treated with what? |
|
Definition
|
|
Term
| Advanced Tumor stage Cutaneous T-Cell lymphoma can be treated with what types of agents |
|
Definition
|
|
Term
| What are the two Poor Prognostic Factors for Multiple Myeloma? |
|
Definition
| Beta-2 microglobulin (frmo MHCI) in serum, as well as high Light Chain monoclonal producing clones |
|
|
Term
| What radiological studies should be performed on Multiple Myeloma patients? |
|
Definition
| MRI with contrast to detect possible bone degredation/tumors (since spinal cord compression can occur) |
|
|
Term
| What are two treatment options for Multiple Myeloma? |
|
Definition
| Lenalidomide and Bortezomib |
|
|
Term
| What can be given to reduce bone distruction in Multiple Myeloma and what are the downsides? |
|
Definition
| Bisphosphonates; Osteonecrosis of the Jaw can occur in patients with dental problems |
|
|
Term
| What is the disorder characterized by Diffuse Indolent lymphoma and secreting Monoclonal IgM? |
|
Definition
| Waldenstrom Macroglobulinemia |
|
|
Term
| What is immediate treatment for Waldenstrom Macroglobulinemia? |
|
Definition
| Plasma removal and replacement with saline/albumin |
|
|
Term
| Why does Uric Acid increase when treating cancer? |
|
Definition
| DNA degredation triggers the purine degredation pathway leading to excess Uric Acid |
|
|
Term
| What are the poor prognostic factors for CLL? |
|
Definition
| A doubling time <12 mo, Increased beta-2 microglobulin, Increased LDH, 17p- |
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