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LS2 Lecture 7
midterm 2
71
Biology
Undergraduate 2
07/08/2009

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Term
What is the nervous system made of?
Definition
billions of neurons
Term
How do neurons communicate with each other and with other cells in the body?
Definition
through electrical and chemical signals (movement of ions)
Term
What is the function of the nervous system?
Definition
1. to receive info 2. to interpret info 3. to act on it
Term
How much of the brain do neurons constitute?
Definition
10% of the brain
Term
What is the cell body?
Definition
the central command of the cell where the nucleus is located
Term
What are dendrites?
Definition
extensions of the cell body that receive electrical signals
Term
Is a neuron the same shape as a regular cell?
Definition
no, a regular cell is spherical. Neuron has a different shape than typical cell because its function is different.
Term
What is the director of the cell?
Definition
cell body
Term
How many dendrites can exist?
Definition
up to 50,000 dendrites depending on the location of neuron
Term
What do axons do?
Definition
conduct impulse away from the cell body
Term
What do axon terminals contain?
Definition
vesicles with neurotransmitter
Term
What do axons allow?
Definition
electrical signal to travel from one place to another
Term
Which way do axons carry electrical signals?
Definition
Away from the cell body
Term
What are the end branches called?
Definition
axon terminals
Term
What are schwann cells?
Definition
produce myelin that insulate the axon
Term
What are nodes of ranvier?
Definition
gaps in myelin sheath along the axon
Term
Are schwann cells neurons?
Definition
No, they help neurons functions
Term
Where are schwann cells found?
Definition
only found around axon
Term
What is the function of schwann cells?
Definition
to speed up electrical signals
Term
What do afferent neurons do?
Definition
They send information to the central nervous system (CNS). (input, going into brain)
Term
What do interneurons do?
Definition
connect neurons within the CNS (processing, interpretation of info)
Term
What do efferent neurons do?
Definition
send information from the CNS (coming out of brain, output of brain)
Term
Do all neurons have the same function?
Definition
no
Term
Describe multipolar neurons
Definition
1. have many dendrites but 1 axon 2. found in the brain and spinal cord
Term
Describe bipolar neurons
Definition
1. have 2 processes 2. one is an axon, the other is a dendrite 3. found in eyes, nose (get rest)
Term
Describe unipolar neurons
Definition
1. have a single process 2. this process branches into two 3. one branch is associated with dendrites, the other enters the ganglia which is clusters of cell body 4. the cell bodies aggregate forming ganglia
Term
What is a synapse?
Definition
connection between neurons
Term
What do two neurons form?
Definition
a junction
Term
What is the neuron sending the signal called?
Definition
presynaptic neuron
Term
What is the neuron receiving the signal called?
Definition
the postsynaptic neuron
Term
Can a neuron receive or send many signals?
Definition
yes
Term
How are neurons like a web?
Definition
they are connected all over the place
Term
Can a neuron form many synapses?
Definition
yes
Term
What is an action potential?
Definition
shows a change in voltage over a period of time, huge change in voltage
Term
What is a graded potential?
Definition
small change in voltage
Term
Where is the action potential?
Definition
at the axon hillock
Term
What does a neurotransmitter release lead to?
Definition
axon terminal
Term
In reality should there be a change difference between the inside and outside of the neuron?
Definition
yes there must be
Term
In a neuron what is the ECF?
Definition
extracellular fluid: Na and Cl
Term
What is the ICF?
Definition
intracellular fluid: K and anions
Term
What is the charge difference in the inside of the neuron?
Definition
-70mV
Term
Is there a huge charge difference between the inside and outside of a neuron?
Definition
yes
Term
The larger the charge difference...
Definition
the higher the potential will be
Term
Are ion channels specific?
Definition
yes
Term
What does the Na/K pump prevent?
Definition
equilibrium. moves by active transport and is constantly maintaing gradient of ions. requires ATP. Na is high on outside, K is high on inside
Term
Why is the squid called the giant axon?
Definition
We study neurons through squid because the axon is big enough to see with the human eye
Term
What is depolarization?
Definition
when membrane potential is less negative than resting potential
Term
What is hyperpolarization?
Definition
when membrane potential is more negative than resting potential
Term
What is repolarization?
Definition
when a membrane potential has been depolarized (or hyperpolarized), returns to its resting value
Term
What is threshold potential?
Definition
amount of electrical activity needed to have action potential
Term
What causes an increase in voltage?
Definition
sodium getting into cell
Term
What causes a decrease in voltage?
Definition
potassium getting out of cell
Term
What will happen in an action potential?
Definition
the membrane will depolarize, repolarize, and then hyperpolarize
Term
Which two voltage gated channels play a major role in action potential?
Definition
1. voltage gated sodium channel 2. voltage gated potassium channel 3. open and close based on voltage change
Term
Describe a voltage gated sodium channel, its function, and its three states.
Definition
1. a protein channel that is specific to sodium 2. triggered to open at threshold potential 3. 3 states: closed at resting potential, open (-50mV)-(+30mV), inactivated (+30mV)-(-70mV)
Term
Can leak channels always be activated?
Definition
yes but only allow a small amount
Term
Describe a voltage gated potassium channel, its function, and its two states.
Definition
1. a protein channel that is specific to potassium 2. triggered to open at threshold potential 3. has two states: closed at resting potential (-70mV)-(+30mV), open (+30mV)-(-80mV)
Term
Are voltage gated channels stronger or leak gated channels?
Definition
voltage gated channels
Term
what is TTX and what does it do?
Definition
1. Tetradotoxin 2. inhibitor, blocks voltage gated channel from being active 3. blocks neurons so electrical activity cannot occur and brain shuts down 4. found in pufferfish
Term
What happens once the action potential occurs?
Definition
depolarization spreads to other parts of the axons
Term
What does the depolarization trigger?
Definition
VGSC to open and more action potentials to occur
Term
What does myelin do to the action potential?
Definition
it speeds up he spreading of the action potential
Term
Where do schwann cells make myelin?
Definition
in PNS
Term
Where do oligodendroctes make myelin?
Definition
in the CNS
Term
What does myelin do?
Definition
speeds up electrical activities
Term
Where are all the voltage gated channels found?
Definition
in the nodes of ranvier
Term
What is saltatory conductance?
Definition
traveling of the electrical signal
Term
Where do changes inside the neuron happen?
Definition
only inside the neuron
Term
How is myelin like an insulator?
Definition
it insulates activity inside neuron and does not let it leak to outside
Term
Describe the events that happen at the synapse
Definition
1. action potential arrives at the axon terminals 2. the depolarization of the action potential stimulates the voltage gated calcium channels to open 3. calcium influx causes the mobilization of the vesicles containing neurotransmitters 4. neurotransmitters bind to receptors on postsynaptic cell 5. depolarization occurs causing series of events that leads to action potential
Term
Can neurons pass activity to other neurons?
Definition
yes
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