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Lecture 8
Lipids as signal transduction
7
Biology
Graduate
07/04/2014

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Term
What is  phospholipase?
Definition

Enzymes that cleave lipids

 

Term
What is the classes of phospholipapses?
Definition

A1 – cleave first fatty acid

A2 – cleave second fatty acid

C – cleave head with phosphate

D – cleave bear head group

 

Term
What is the mode of action of phospholipapse A2?
Definition
Phosphatidylcholine →  free fatty acid + LysoPC . Fatty acid connects to the hormone response (Jasmonic acid) → gene expression
Term
What is the mode of action of phospholipase C?
Definition

Phosphatidylinositol → DAG + IP3 .

Phosphatidylinositol is a clear signal lipid. It contains sugar and phosphogroup.

 

Activation state – creation of PIP2, activation of GTP → sugar into cytosol → activate lipid activating channels. No IP present – channels are closed.

 

If we have DAG and Ca2+ → activation of PKC (activated only if previous path is activated)

Term
What is the mode of action of phosphotidase D?
Definition

Phosphatidylcholine →  Phophatidate + (choline) . PLD for activation requires Ca2+ and CalB. No indication, that cholin give signal

 

Term
Describe the mechanism of leaf opening
Definition

bulliform cells (open or close leaves) → pump in ions → water into the cells → expenditure of the cells → leaf is open. This process could be dependent from ATP!

 

Term
Describe the mechanism of stomata opening
Definition
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