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Lecture 7
Important Terms
21
Biology
Undergraduate 2
10/09/2011

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Term
Genetic Linkage Mapping
Definition
A representation of the relative distances separating genes on a chromosome based on the frequencies of recombination between nonallelic gene loci
Term
Locus
Definition
The position of a gene on a genetic map; the specific place on a chromosome where a gene is located
Term
Complete Linkage
Definition
Genes on a chromosome are inherited together with no exchange or crossing over
Term
Recombination
Definition
A process by which parents with different alleles give rise to progeny with genotypes that differ from either parent
Term
Parental Class
Definition
Original arrangement of alleles on the two chromosomes
Term
Recombinant classes
Definition
Rearrangements of the arrangement of the alleles on the original chromosome
Term
Coupling (cis)
Definition
Two wild type alleles on one homolog & two recessive alleles on the other
Term
Repulsion (trans)
Definition
one wild type & one recessive allele on each homolog
Term
Crossing-Over
Definition
The process of reciprocal chromosomal interchange that occurs frequently during meiosis and gives rise to recombinant chromosomes
Term
Chiasma
Definition
A cross-shaped structure formed during crossing-over and visible during the diplonema stage of meiosis
Term
Three-Point Testcross
Definition
A cross between an individual heterozygous at three loci with an individual homozygous for recessive alleles at the same three loci
Term
Interlocus Distance
Definition
Distance between two genes on a chromosome
Term
Recombination Frequency
Definition
Percentage of offspring resulting from recombinant gametes
Term
Map Unit (mu)
Definition
= 1% recombination between two genes on a chromosome
Term
centiMorgans (cM)
Definition
Measurement of map distance which is equal to one map unit
Term
Single Crossovers (SCOs)
Definition
Can be used to determine the distance between 2 genes
Term
Double Crossovers (DCOs)
Definition
Can be used to determine the order of 3 genes on the chromosome
Term
Coefficient of Coincidence
Definition
= Observed DCOs/Expected DCOs
Term
Interference
Definition
=1-CC
Relation between expected DCOs and actual DCOs
Term
Map Distance
Definition
Genetic distances based on recombination frequencies are not the same as "physical distances" between two genes
Term
Two-Point Mapping
Definition
Used to determine the distance in mu/cM between two genes
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