Term
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Definition
| immunological active region of an immunogen that binds to antigen-specific membrane receptors on lymphocytes or to secreted antibodies. |
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Term
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Definition
| ability to induce a humoral and/or cell-mediated immune response |
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Term
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Definition
| ability to combine specifically with secreted antibodies and/or surface receptors on T cells |
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Term
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Definition
small molecule
antigenic, but incapable of inducing a specific immune response (no immunogenicity)
low-MW molecule that can be made immunogenic by conjugation to a suitable carrier |
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Term
| What 4 properties of an immunogen affect immunogenicity? |
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Definition
1) Foreignness,
2) Molecular size
3) chemical composition and complexity
4) ability to process and present with an MHC molecule on surface of APC or altered self cell |
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Term
| How big are the most active immunogens? |
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Definition
>10,000 daltons
mm < 5000-10,000 are poor immunogens
some substances with MM<1000Da are active |
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Term
| How does a B cell interact with antigen? |
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Definition
| involves binary complex of membrane Ig and Ag |
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Term
| How does a T cell interact with antigen? |
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Definition
| involves ternary complex of T-cell receptor, Ag and MHC molecule |
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Term
| Do B and T cells bind soluble antigen? |
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Definition
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Term
| Are MHC molecules required for B cells to recognize antigen? T cells? |
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Definition
B cells - no
T cells - yes |
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Term
| What are the properties of epitopes that bind to B cells? |
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Definition
accessible
hydrophilic
mobile peptides containing sequential or nonsequential aa |
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Term
| What are the properties of epitopes that bind to T cells? |
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Definition
| Internal linear peptides produced by processing of antigen and bound to MHC molecules |
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Term
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Definition
Complementarity-determining region
portions of the variable regions of antibody molecules that protrude from the V domains and have the potential to contact antigens. The antigen-binding sites of antibody molecules are composed of the CDRs. |
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Term
| Which Immunoglobulin classes have subclasses and what are they? |
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Definition
IgG - gamma 1-4 (heavy chain gamma)
IgA alpha 1 and 2 (heavy chain alpha) |
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Term
| What are the 5 classes of Ig? |
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Definition
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