Term
| What is genetics vs genomics? |
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Definition
genetics = study of heredity, genes & their effects
genomics = study of entire genome and the interactions between multiple genes & the environment |
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Term
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Definition
| the study of how food compounds affect a person's health, based on their genetic makeup |
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Term
| How are nutrients & genes linked? |
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Definition
| food compounds can upregulate or downregulate transcription factors, changing gene transcription activity and affecting how cells proliferate, function etc. |
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Term
| What is the link between dietary calcium & colon cancer? |
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Definition
| individuals with a 'ff' genotype are at an increased risk of developing colon cancer if they are on a low calcium diet |
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Term
| What are some of the concerns with marketing foods based on nutrigenomics? |
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Definition
-can create false sense of security
-may be ineffective or even harmful
-may reduce use of other health seervices
-claims may be misleading |
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Term
| Why does albuterol not affect all patients the same way? |
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Definition
| Patients with a Gly-Gly receptor genotype respond to albuterol poorly, whereas Arg-Arg genotype patients have a much better response rate |
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Term
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Definition
| glues segments of DNA together e.g. a synthetic gene fragment + vector DNA |
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Term
| What is the association between Angelman syndrome & Prader-Willi syndrome? |
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Definition
| both involve the same deletion on chromosome 15 |
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Term
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Definition
| studying changes in how gene expression is regulated, in ways that are not depending on DNA sequenece |
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Term
| What effect might upregulation of histone deacetylases have on gene expression? |
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Definition
| would reduce gene expression (histone complexes need to be acetylated to allow for gene transcription) |
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Term
| RPE65 mutations result in.... |
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Definition
| leber congenital amaurosis (retinal disease = blindness) |
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