Term
| What are the two main drugs we look to for HSV Keratitis? |
|
Definition
| Trifluridine 1% sol and Gancicluvir 0.15% gel |
|
|
Term
| Dosing for Trifluridine vs HSV Keratitis |
|
Definition
| Q2H (max 9 drops) until healed, then QID or Q4-5H for 1 week |
|
|
Term
| When using trifluridine, improvement of HSV Keratitis should start within ___ days and resolve within ___ days, but don't use it over ___ days. |
|
Definition
|
|
Term
| Dosing for Ganciclovir vs HSV Keratitis |
|
Definition
| 5x/day (~Q3H) until healed, then TID for 1 week |
|
|
Term
| Interferons heal up HSV Keratitis faster than the typical antivirals, but... |
|
Definition
| …they end up taking the same amount of time to completely resolve. |
|
|
Term
| Some snotty little kid has EKC. What do you use and what do you do with it? |
|
Definition
1 drop proparicaine
4-5 drops Betadine
RINSE, give 1-2 drops NSAID
(Consider Lotemax QID for 4 days) |
|
|
Term
Acyclovir =
____ mg __x/day for __ days if Zoster,
____ mg __x/day for __ days if Simplex. |
|
Definition
Z: 800mg 5x/day for 7 days
S: 400mg 5x/day for 7 days |
|
|
Term
Valacyclovir =
____ mg __x/day for __ days if Zoster,
____ mg __x/day for __ days if Simplex. |
|
Definition
Z: 1000mg 3x/day for 7 days
S: 500mg 3x/day for 7 days |
|
|
Term
Famciclovir =
____ mg __x/day for __ days if Zoster,
____ mg __x/day for __ days if Simplex. |
|
Definition
Z: 500mg 3x/day for 7 days
S: 250mg 3x/day for 7 days |
|
|
Term
| What drugs could you give for CMV? Which one is the only treatment approved by the FDA? |
|
Definition
Ganciclovir
Valganciclovir
Foscarnet
Cidofovir
Foscarnet is the FDA-approved tx. |
|
|
Term
| What is the mechanism of action of all commercially-available antivirals today? |
|
Definition
|
|
Term
| What is the drug of choice for HSV keratitis? |
|
Definition
| Trifluridine (9x/d till healed, QID/1wk) or Ganciclovir (5x/d till healed, TID/1wk) |
|
|
Term
| Recurrent HSV keratitis indicates permanent dosing of… |
|
Definition
|
|
Term
| Why is trifluridine indicated for simplex but not really zoster? |
|
Definition
| Because simplex is infectious, but zoster is just inflammatory. |
|
|
Term
| Why is ganciclovir C/I in AIDS patients? |
|
Definition
| Because of the possibility of bone marrow suppression. |
|
|
