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Lect 6
Anti-Infectives
31
Medical
Graduate
02/20/2013

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Cards

Term
Eye doctors don't really cause resistance with our little drops, but when it comes to antibiotics in general, what's a pretty good rule of thumb when it comes to resistance?
Definition
Don't Rx sub-therapeutic doses.
Term
What type of drugs are analagous to The A-Team's Murdock? (They're good at what they do, need to be combined with other meds (can't really work alone), and may not really be picked first.)
Definition
Polymyxin B
(Gotta myxin another drug.)

Our Polymixin B combos are Polysporin (w/ Bacitracin), Polytrim (w/ Trimethoprim) and Neosporin (w/ Neomycin).
Term
What is Bacitracin's spectrum?
Definition
Gram +
Term
What is Polymyxin B's spectrum?
Definition
Most Gram -
Term
Erythromycin vs Bacitracin on bleph. Go.
Definition
Bacitracin
Term
Polysporin might be better for (daytime / bedtime)
Definition
Bedtime so they don't have to use a steroid drop sitting on their eye all night.
Term
Polytrim's good for children, yes?
Definition
Yes.

High efficacy against the most common causes of bacterial eye infections in kids. In fact, pediatricians are the largest prescribers of Polytrim.
Term
What's neomycin's problem?
Definition
Can cause a contact dermatitis.
Term
What type of drugs are analagous to The A-Team's Hannibal? (They're not the strongest, but a good class of drugs to turn to.)
Definition
Aminoglycosides
Term
What common drug may inactivate aminoglycosides?
Definition
Penicillins
Term
What aminoglycoside has "two eyes"?
Definition
Gentamicin
Term
Are there generics for Tobramycin?
Definition
*****
Yes
*****
Term
About 50% of patients who are allergic to neomycin are also allergic to what aminoglycoside?
Definition
Gentamicin
Term
Besides vancomycin, what is considered a DOC for MRSA?
Definition
Gentamicin
Term
What type of drugs are analagous to The A-Team's Face? (They're solid with low amounts of toxicity, but may not be the first ones you go with.)
Definition
Macrolides
Term
What macrolide makes a much better prophylactic than DOC for active therapy?
Definition
Erythomycin
Term
What's awesome about AzaSite? What's not so awesome?
Definition
Good: It's like a Z-PAK: bid x 2 days; qd x 5 days

But it stings.

Also, it's pretty high viscosity, so you have to make sure you don't squeeze it too hard or else you'll get it all over your face. (…That's what she said.)
Term
Who's our BA Barakas?
Definition
I pity the Fluoroquinolones!
Term
Which fluoroquinolone is bringing the big, big guns?
Definition
Besifloxacin - effectiveness equal to vancomycin and there's no resistance
Term
What is Moxeza's dosing and why?
Definition
*****
1 gtt bid x 7 days
*****

…because the xantham gum keeps it on the eye longer.
Term
What's gatifloxacin's preservative and why might it actually be a good thing to have around?
Definition
BAK

Since it's antibacterial in its preservative role, that's kind of exactly what you're looking for.
Term
Ciprofloxacin is approved for bacterial conjunctivitis and ___________.
Definition
*****
keratitis
*****
Term
Ofloxacin is single-agent therapy for bacterial __________.
Definition
*****
keratitis
*****
Term
If you're going to use a fluoroquinolone, which one is the only one Melton and Thomas will back?
Definition
Besi
Term
What superstar AB/Steroid combo is available as a generic now?
Definition
*****
TobraDex
*****
Term
What drugs are in the Zylet combo?
Definition
loteprednol and tobramycin
Term
What drug do you use for acne rosacia (or RCE, for that matter)?
Definition
Doxy!
Term
What side effect did Dr. Horn totally get nailed with by one of his early patients? What drug was the culprit?
Definition
Photosensitivity from Tetracyclines
Term
What antibiotics do you keep away from kids or people who are growing kids?
Definition
Tetracyclines
Term
What headache thingy might you see with the use of tetracyclines?
Definition
IIH / pseudotumor cerebri
Term
What's the only antifungal drop that doesn't have to be compounded by the pharmacist? (ie. it's the only commercially-prepared topical antifungal)
Definition
Natamycin 5%
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