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lab 8
ointment bases and levigation
32
Other
Not Applicable
04/26/2012

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Term
ointments 
Definition
semi solid dosage forms intended for topical application 
Term
use of unmedicated ointments 
Definition

physical effects: protectants, emollients, or lubricants

 

can also be vehicles for medicated ointments 

Term
four classes of ointment bases
Definition
  1. hydrocarbon bases
  2. absorption bases
  3. water removable bases
  4. water soluble bases 
Term
hydrocarbon bases
Definition

 

  • provide emollient effect
  • protect against the escape of moisture
  • occlusive dressing
  • remain on skin for long periods without drying out 
  • contain oleaginous ingredients 
  • water - immiscible , difficult to wash off
examples: petrolatum, white petrolatum, white ointment, yellow ointment 

 

Term
petrolatum, white petrolatum, white and yellow ointment 
Definition
examples of hydrocarbon bases
Term
absorption bases
Definition
  • water absorbing or emulsifying property
  • can absorb reasonable amounts of water or aqueous solutions without losing consistency
  • AKA emulsifiable ointment bases
  • dont provide occlusion provided by hydrocarbon bases
  • not easily water washable, external phase is oleaginous 
  • useful when small volumes of aqueous solutions need to be incorporated into hydrocarbon bases 
Term
two types of absorption bases
Definition
anhydrous and hydrous 
Term
anhydrous absorption base 
Definition
permit incorporation of aq solutions resulting in formula of water in oil emulsion 
Term
hydrous absorption base 
Definition
  • contain water
  • water in oil emulsion. also called emulsion bases. permit incorporation of additional quantities of water but only accept limited amounts of water because they already contain it. 
Term
hydrophilic petrolatum USP, polysorb, aquaphor 
Definition
anhydrous absorption bases
Term
hydrous lanolin, cold cream, nivea, eucerin 
Definition
hydrous absorption bases, aka emulsion bases
Term
water removable bases
Definition

oil in water emulsions 

 

water washable: can be readily washed from skin or clothing with water. 

water is external phase so these bases may be diluted with water 

 

ex: hydrophilic ointment 

Term

hydrophilic ointment 

Definition
a water removable base
Term
water soluble base
Definition

"greaseless ointment bases" 

 

contain water soluble constituents only. 

 

 

ex: polyethylene glycol ointment 

Term
polyethylene glycol ointment 
Definition
water soluble base
Term
what type of emulsion is formed when water is added to aquaphor ? 
Definition
w/o 
Term
transdermal drug delivery systems (TDDS)
Definition
dermatological preparations for systemic effect 
Term
locally acting topical agents that have limited chemical or pharmacological activity have a ________ basis of action 
Definition
physical basis of action 
Term
examples that have a physical basis of action (locally acting)
Definition
protectives, adsorbents, demulcents, emollients, cleansing agents 
Term
topical agents with a general CHEMICAL reactivity include
Definition
astringents, irritants, rubefacients, vesicants, sclerosing agents, caustics, escharotics, and keratolytic agents 
Term
levigation 
Definition

technique used if the substance to be incorporated into a vehicle is a powder. 

 

the technique uses an intervening liquid in which the powder is insoluble. 

 

the process of grinding a solid between hard surfaces in the presence of a liquid in which the solid is not soluble until it has been reduced to a fine almost impalpable material. 

Term
levigating agent can also be called 
Definition
dispersing agent 
Term
levigating agent 
Definition
the intervening liquid in which the powder to be incorporated into a vehcile is insoluble 
Term
pastes
Definition
contain a larger concentration of solids which can be dispersed into the vehicle without the aid of a levigating agent 
Term
levigating agent + paste is a no no because... 
Definition
levigating agent can soften the paste and make it look like an ointment 
Term
example of levigating agent in pastes that call for one 
Definition
use a little bit of the base !
Term
most frequently used levigating agents 
Definition
mineral oil and glycerin 
Term
mineral oil 
Definition
levigating agent used for ointment bases in which oils are the external phase 
Term
glycerin 
Definition
levigating agent used for ointment bases in which water is the external phase 
Term
another name for zinc oxide paste
Definition
Lassar's Zinc oxide paste
Term
precipitated sulfur
Definition
used for skin diseases
Term
colloidal sulfur 
Definition
used for acne 
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