Shared Flashcard Set

Details

kin. 601
Respiratory Physiology (gas transport by the blood)
56
Science
Undergraduate 4
04/18/2009

Additional Science Flashcards

 


 

Cards

Term
what are the two ways 02 is carried in the blood?
Definition
O2 can either be dissolved or bound to hemeoglobin
Term
what is the fick equation?
Definition
V02 = Q x (a - V02)
Term
Transport equation?
Definition
Ca02 = (1.34 x HB x Sa02)+(.003 x P02)
Term
values for HB within the tansport equation
Definition
HB = 15 ml/dl
Term
values for Sa02 within the transport equation
Definition
Sa02 = 97%
Term
percent dissolved oxygen
Definition
3%
Term
percent bound to hemeoglobin
Definition
97%
Term
The amount of dissolved 02 in the blood is proportional to.....
Definition
The pressure of oxygen (times) the Solubility (.003 x 100)
Term
How many binding sites does 1 hemeoglobin have?
Definition
4
Term
how many heme groups? what are they?
Definition
2 alpha, 2 beta, there are 4 heme groups
Term
what does ferrous state mean?
Definition
normal state not binded with oxygen
Term
whole blood carries ____ more oxygen at a P02 o 100 than does plasma
Definition
65x
Term
1 gram of hemeoglobin combinds with how much oxygen?
Definition
1.34 ml/oxygen
Term
what is methemeoglobin? (2 answers)
Definition
formed during the transformation of oxyhemeoglobin. It is the byproduct of the binding with oxygen
Term
02 containing form is called?
Definition
oxyhemeoglobin (Hb02)
Term
Is HB the reduced form or the oxygen form?
Definition
reduced form
Term
Is Hb03 the reduced form or the oxygen form?
Definition
oxygen form
Term
02 saturation of hemeoglobin (transport equation)
Definition
Sa02
Term
why is the Sa02 = to 97% and not 100%
Definition
shunts, V/Q missmatch, diffusion limitations, hypoventilation
Term
mixed venous blood with a p02 of 40 is about? (percent)
Definition
75%
Term
unoxygenated form of hemeoglonbin is called?
Definition
deoxyhemeoglobin (HB)
Term
What shape is the 02 dissociation curve?
Definition
sigmoidal
Term
Sequence for heme binding (4 steps)
Definition
hard, easier, easy, more diffcult
Term
what does the P50 mean?
Definition
the P02 for 50% saturation (26 mmHg)
Term
explain loading
Definition
PA02 70 - 100 mmhg, involves the lungs
Term
explain unloading
Definition
Pcap = 40 mmhg, involves the tissue
Term
explain the functional importance of flat upper portion of the curve. why?
Definition
CA02 does not change much when p02
falls to about 70 mmHg,because of V/Q missmatch, hypoventilation, and low ambient P02.
Term
the Hb02 curve can be affected in 2 ways
Definition
1. change in position (P50)
2. change of the shape of the curve due to diseases. (Hills N)
Term
where is myoglobin found?
Definition
in the muscle, storage form of oxygen.
Term
what is the effect of myoglobin within the 02 transport?
Definition
accepts 02 readily but releases it only at low P02.unsuited for 02 transport in the blood, but useful in skeletal muscle.
Term
explain carboxyhemoglobin
Definition
CO produced by incomplete combustion, binds at same site, forms caroxyhemeoglobin (COHb), 250 x greater than 02, small amounts can interfere with binding, uses up binding sites, shifts curve to the left (decreases the P50), decreases oxygen delivery.
Term
Hb02 curve : shift to the right means...
Definition
decreased infinty, reduces the quantity of 02 that can be taken up
Term
steep portion of the curve (values)
Definition
30 to 40 mmHg
Term
Hb02 curve: shift to the left
Definition
increase in infinity, increase in binding of 02 to hemeoglobin.
Term
what else is the effect on H+ called?
Definition
Bohr effect
Term
hydrogen ions have a greater affinity for oxyhemeoglobin or reduced hemeoglobin (Hb)?
Definition
reduced hemeoglobin(Hb)
Term
incresed H+ means incresed or decreased PH?
Definition
decresed PH (more acidic)
Term
decreased H+ mean increased or decreased PH
Definition
increase in PH (more basic)
Term
curve shifts to the right or left with increased H+ or PC02?
Definition
curve shifts to the right
Term
increaed temp shifts the curve to the right or left?
Definition
right
Term
decreased temp shifts curve to the lefts or right?
Definition
left shift, favors association with 02 and Hb
Term
what is the standard DPG?
Definition
2,3 DPG
Term
increased 2,3 DPG shifts curve to the right or left?
Definition
shifts curve to the right
Term
2,3 DPG binds with Hb or Hb02 better?
Definition
Hb
Term
what is 2,3 DPG?
Definition
end product of red cell metabolsim
Term
what happens when 2,3 DGP is stored after blood transfusions?
Definition
It tends to decrease
Term
2,3 DPG increases or decrease in hypoxemia?
Definition
increase
Term
2,3 DPG increases or decrease in chronic hypoxia?
Definition
increase
Term
2,3 DPG increases or decrease when blood (H ion +) decreases?
Definition
increase
Term
normal adult hemeoglobin is called
Definition
Type A hemeoglobin
Term
normal adult hemeoglobin is called?
Definition
Type A hemeoglobin
Term
what is HbF? (3)
Definition
fetal hemeoglobin, as a greater infinty for 02, shifts curve to the left.
Term
change the shape of the curve has what type of effect?
Definition
a negative effect on 02 transport, increase in infinity, and decrease in unloading perfomance.
Term
anemia
breathing does not regulate _______
Definition
hemeoglobin concentration, curve moves down to reflect the reduction in 02 capacity. it does not effect saturation but 02 content
Term
anemia
breathing does not regulate _______
Definition
hemeoglobin concentration, curve moves down to reflect the reduction in 02 capacity. it does not effect saturation but 02 content
Term
polycythemia
causes an increase______
Definition
02 content
Supporting users have an ad free experience!