Term
| What pathway in the brain is important in reward pathway? |
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Definition
| DA release in nuc accumbens, innervated from Ventral Tegmental Area. |
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Term
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Definition
Converts acetaldeyde to acetic acid.
If too much acetaldehyde builds up --> sweating, flushing, HA. |
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Term
| What happens acutly with Morphine? |
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Definition
| decreased cAMP levels in nn |
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Term
What happens when Morphine doesn't surpress cAMP?
What happens when you remove morphine? |
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Definition
Tolerance.
Increase leveles of cAMP (withdrawal) |
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Term
| Is it likely that a pt can go from substance dependance to non-problem use? |
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Definition
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Term
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Definition
Blocks DA reuptake --> euphoria
at high levels , blocks V gated Ca channels --> no pain
Blocks uptake of NE (minimize bleeding). |
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Term
| What are the consequences of cocaine use? |
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Definition
Tremors, seizures, convulsions.
Resp.depression.
Cardiovascular: atherosclerosis |
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Term
|
Definition
GABAa receptor activity
increased or more rapid metabolism of Rx |
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Term
|
Definition
Enzyme induction
Diuresis: dec in ADH
Resp Depression: GABA mediated hyperpolarization of nn in resp center.
CV: dec contractilibility, vasodilation
Esophagitis, GI bleeding
Cirrhosis of liver: depletion of NAD+ in liver, liver cant metabolize FFAs --> fatty buildup, acetylaldehyde build up
Teratogenic: Fetal Alcohol Syndrome (FAS)
Wernike-korsokaof |
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Term
| What Rx can you use for Rx? |
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Definition
Naltreoxne
Acamprosate
Disulfram
Compliance is a challenge. |
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Term
| What are cannabinoid receptors? |
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Definition
CB1: mediate psychoactive properties
CB2: involved in nausea |
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Term
| Whats a predictive risk factor of drug abuse? |
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Definition
| Age which they start using. |
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Term
|
Definition
Rx marijuana
antiemetic
appetite stimulation |
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Term
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Definition
speed, uppers.
Stimulants.
Increase wakefullness: military pilots.
ADHD
Anorexia
Narcolepsy |
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Term
| What is the MOA of Amphatamines? |
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Definition
Increase NE/DA release
Block NE/DA uptake
Stimulates NE/DA Receptors
Inhibit MOA
Basically increase NE and DA. |
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Term
| Amphatamines abuse causes what? |
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Definition
CVA -HTN
Hyperpyrexia: increase temp --> convulsions, coma
induced phychosis |
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