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IX. Structure and function of the cell I
Organelles,cytoskeleton
40
Anatomy
Undergraduate 2
09/25/2013

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Term
What is a cell?

what type of solution is cytoplasm
Definition
structural and functional unit- smallest living unit of matter
provides basic template for activity
subcellular structures make the cell's function possible
continuity of life has a cellular basis

colloid
Term
Mitochondria
Definition
cell power house- energy production
aerobic cellular respiration
inner membrane folds with cristae
outer membrane smooth
Term
What is the structure of the inner and outer membrane of the mitochondria
Definition
inner membrane has folds of critae
outer membrane is smooth
Term
what is the purpose of the cristae in the mitochondria?
Definition
to increase its surface area, more room for activity
Term
Mitochondria has it's own
Definition
DNA that replicates
Term
Ribosomes (RNA and Protein)
free
bound
subunits
Definition
involves protein synthesis
free- suspended in cytosol
bound- bound to endoplasmic reticulum
subunits: large: peptide bond formation
small: together with large subunit will bind mRNA and tRNA
Term
Endoplasmic reticulum
what its folds
rough
smooth
Definition
continuous from nuclear membrane- single membrane
folds from cisternae
cavity contains cytoplasm

rough- ribosomes attached cells secreting a product

smooth- no ribosomes attached, embedded enzymes involved in lipid metabolism; cholesterol and steroid hormone synthesis; drug detox. liver
modified-sarcoplasmic reticulum, skeletal and cardiac muscle cells, conducts action potentials
Term
Golgi apparatus
transport vesicles
secretory vesicles
Definition
flattened membrane sacs. modified proteins in secretory cells
transport vesicles- RER to Golgi; cis face
secretory vesicles- gogli to membrane; trans face contents exocytosed into blood stream; travel to plasma membrane
Term
What are the organelles that destroy
Definition
lysosomes, peroxisome, proteasome*
Term
lysosome
what enyzme do they use?
Definition
-cell digestion: old organelles; endocytosed particle; thyroid hormone released
Acid hydrolases: enzymes; low PH; membrane contains proton pump conentrates H +...ATP driven

-aytolysisi self cell destruction. embryology (webbed feet), menstruation, arthritis
Term
Proteasome
Definition
quaternary structure
multienzyme complex, not membrane bound
destroys proteins
has two capped end, central digestive tunnel which is formed by 4 stacked rings, 7 subjunits surround central digestive channel. regulatory caps is gate keepers, regulates what' being destroyed
Term
Peroxisome
Definition
small membrane bound vesicles; liver, kidney detoxification
1. detoxification
- oxidase enzymes- abudnant in liver and kideny to oxidize organic substance; forms hydrogen peroxide
- free radicals- break down; has unpaired electron; highly reactive; cause aging
2.Self replicating- fission or denovo from endoplasmic reticulum; no DNA

also involved in lipid breakdown and bile synthesis
Term
Organelles that form the support system AKA cytoskeleton. 3
Definition
microtubules
microfilament
intermediate filament
Term
microtubules
what are made out of microtubules
where do microtubules arise
what is MTOC
what is a centriole
Definition
hollow tubules of protein tubulin grow and disassemble
support and move organelles--> motor proteins called kinesins, dynein powered by ATP attached organelles can move along the microtubules, microtubules can slide past each other
cilia and flagella are made out of microtubules

microtubules arise from centrosomes

MTOC is microtubule organizing center and contains centrioles

centriole are 2 hollow cylinders. 9 tirplets of microtubules anchoring point for microtubules plus organizes the mitotic spindle
Term
cilia
flagella
Definition
cellular extnesions that propel substance along cell a lot in respiratory track
flagella- propel cell, only in sperm
Term
microfilament
made out of
interact with
Definition
thin strands of actin
interact with unconvetional myosin for cell motility
help strengthen plasma membrane responsible of cell contractility and motility involved in endo/exocytosis
Term
intermediate filament
Definition
high tensile strength proteins stable and permanent
found in tissues of high stretch and strain like skin, help resis cell tension
Term
inclusion
Definition
stored chemical substances w/in the cell. variable depending on type of cell and function; stored substance ex: glycogen, ,elanin, acetyl coline
Term
nucleus
what are the parts of the nucleus
Definition
organelles that controls
largest organelle
nuclear envelope, nucleoli
Term
nuclear envelope
Definition
double memebrane' outer membrane is continuous with E.R.

perinuclear cisterna (b/t 2 membrane)-filled with fluid
Term
nucleoli
Definition
dark-staining rRNA synthesis
Term
nuclear pores allow RNA to go in and out of the nucleus, T/F
Definition
true
Term
red blood cells contain no nucleus T/F
Definition
true
Term
chromosome
Definition
old generic term used to describe genetic material (chromatin) when its condensed
Term
chromatin
Definition
DNA and histones that are not condensed; thin and threadlike; exist when cell doesn't divide
Term
chromatid
Definition
one of 2 "spiral" filament of condensed chromatin joined at a centromere which make up a chromosome; exist after DNA replication
Term
Where is cristae found
Definition
mitochondria
Term
where is cisternae found
Definition
eNdoplasmic reticulum (rough)
Term
What is modified Endoplasmic reticulum
Definition
sarcoplasmic reticulum- skeletal and cardiac muscle cells. conducts action potential
Term
Where does a transport vesicle go and what is its "face"
Definition
RER to Golgi
cis face
Term
Where does the secretory vesicle go and what is its "face"
Definition
Gogli to membrane; transface (facing away from RER)
Term
What do the lysosomes do
Definition
digest old organellese, substances that have been endocytosed, particpates in thyroid gland
Term
Cells of immune system have a lot of lysosomes true or false
Definition
true
Term
which enzyme involves detoxification?
Definition
peroxisome
Term
what do free radicals cause
Definition
aging
Term
T/F peroxisomes are self replicating
Definition
true
Term
What do microtubules do?
Definition
support and move organelles
made out of cilia and flagella
are centrioles and organizes the mitotic spindle
Term
what do microfilaments do
Definition
thin strands of actin; interac w/ uncoventional myosin for cell motility
help strengthen the plasma membrane
responsible for cell contractility and motitlity
invovled in endo/exocytosis
Term
what do intermediate filaments do
Definition
high tensile strenght proteins
stable and permanent
found in tissues of high stretch and strain; skin
Term
what is perinuclear cistern
Definition
between 2 membrane of nucleus, filled with fluid
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