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ischemic brain disease
pg 403 First AID, 2010
12
Medical
Professional
06/09/2011

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Cards

Term
irreversible damage after how many minutes?
Definition
5
Term
most vulnerable regions
Definition
hippocampus, neocortex, cerebellum, watershed areas
Term
Timeline: (12-48 hrs)
Definition
- red neurons: irreversible damage
Term
Timeline: (24-72 hrs)
Definition
- necrosis + PMN's
Term
Timeline: (3-5 days)
Definition
- macrophages seen
Term
Timeline: (1-2 weeks)
Definition
- reactive gliosis + vascular proliferation
Term
Timeline: (>2 weeks)
Definition
- glial scar
Term
atherosclerosis
Definition
thrombi lead to ischemic stroke w/ subsequent necrosis (red neurons); cystic cavity formed with reactive gliosis
Term
hemorrhagic stroke
Definition
intracerebral bleeding, often due to anuerysm rupture; possible secondary to ischemic stroke after reperfusion b/c of vessel fragility
Term
ischemic stroke
Definition
emboli block large vessels; etiologies include atrial fibrillation, carotid dissection, patent foramen ovale, endocarditis; lacunar strokes block small vessels, are secondary to HTN; Tx = tPA w/in 3 hours
Term
transient ischemic attack
Definition
brief, reversible episode of neurologic dysfunction due to focal ischemia; Sx usually last < 24 hours
Term
Imaging for strokes
Definition
- (3-30 minutes): bright on diffusion-weighted MRI
- remains bright for 10 days
- dark on CT in about 24 days
- CT w/out contrast =
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