Term
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Definition
| decreased blood supply due to mechanical arterial obstruction . which compromises the delivery of substrates for glycolysis . susequently affecting metabolism . |
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Term
| Ischaemia reperfusion . two effects |
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Definition
1. Reperfusion . promote recovery of cells if reversibly injured
2. Exacerbate cell injury (myocardial and cerebral infarction) |
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Term
| Exacerbative Cell injury mechanisms (3) |
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Definition
1. Reoxygenation . generation of reactive oxygen and nitrogen species .
2. Ischaemic injury .inflammation .cytokines.
3. Activation of compliment system . activation of antibodies by IgM. leading to tissue injury |
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Term
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Definition
| Area of ischaemic necrosis due to occlusion of arterial supply of venous drainage |
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Term
| Common Causes of infarcts |
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Definition
thrombotic or embolic occlusions .
plus venous thrombosis(causes congestion.single efferent vein) |
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Term
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Definition
Local vasospasm, heamorrhage into atheromatous plaque ,extrinsic vessel compression .eg.tumour
Vessel Torsion .traumatic rapture . vascular compromise by oedema |
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Term
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Definition
| Venous Occlusion . blood collects in infarcted zone . |
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Term
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Definition
Arterial occlusion in solid organs with end arterial circulation (heart kidneys )
tissue density limits seepage of blood into necrotic area . |
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Term
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Definition
Wedge shaped with occluded vessel at apex. periphery of organ forms base .
if base is serosal surface (outermost layer facing body cavity ) overlying fibrinous exudate .
red blood cells phagocytosed _firm brown residue . |
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Term
| Ischaemic Coagulative Necrosis |
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Definition
| dominanat microscoic characteristic of infarction |
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Term
| Factors that influence development of infarct |
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Definition
NATURE OF VASCULAR SUPPLY . (dual supply which is protective against infarction .
Rate of occlusion development
Vu;lnerability to hypoxia
Oxygen content of blood . |
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Term
| Acute Infarcts Characteristics |
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Definition
| Hyperemic border with dead muscle that is tan yellow inside . |
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