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Intro to Bio final
EBIO 1210 @ CU boulder
44
Biology
Undergraduate 1
12/15/2012

Additional Biology Flashcards

 


 

Cards

Term
Describe the relationship between a DNA molecule and a Gene
Definition
Term
What is a gene in molecular terms
Definition
Term
How is information stored in nucleic acid
Definition
Term
Define Central Dogma
Definition

The process by which we get information out of genes

 

DNA → RNA → Protein

 

Gene expression happens in two fundamental steps in the following order: Transcription → Translation

Term
Major steps in the process of transcription
Definition
  1. Initiation - Figuring out where to start reading DNA and actually begin making RNA
  2. Elongation - make the full length mRNA transcript
  3. Termination - stop transcribing, mRNA is complete
Term
Main molecules involved in transcription
Definition
  1. Promoter
  2. RNA polymerase
  3. bacteria
  4. eukaryotes
Term
Promoter
Definition

Start signal for the gene

 

Directly required for the initiation of translation

Term
RNA polymerase
Definition
  1. Reads one strand of DNA and builds the mRNA
  2. cannot bind to the promoter on its own, and so only binds when certain transcription factors are present
Term
?Bacteria in Transcription
Definition
Provides termination sequence
Term
?Eukaryotes
Definition
Enzymes that cut the transcription free
Term
What is accomplished during the process of transcription
Definition
mRNA is decoded by the ribosomes to produce a specific amino acid chain, or polypeptide that will later fold into an active protein
Term
?Steps in translation
Definition
  1. Initiation
  2. elongation
  3. termination
Term
Main molecules involved in translation
Definition
  1. Codons
  2. amino acids
  3. polypeptides
  4. ribosome
  5. tRNA
  6. Anticodon
Term
Codons
Definition

mRNA triplets

read in 5' --> 3' direction

Term
Amino acids
Definition

An organic molecule possessing both carboxyl and amino groups

Serve as monomers of proteins

Term
polypeptides
Definition
a polymer chain of many amino acids linked together my peptide bonds
Term
Ribosome
Definition
  1. Facilitates the coupling of mRNA codons with tRNA anticodons
  2. provides a physical site for translation in which all the participating molecules find their proper spatial arrangement
  3. catalyzes formation for peptide bonds
Term
tRNA
Definition
  1. Transfer RNA
  2. RNA molecule that brings amino acids into the ribosome
Term
Anticodon
Definition
A unit made up of 3 nucleotides that correspond to the three bases of the codon on the mRNA. Each tRNA brings a specific anticodon triplet sequence that can base-pair to one or more codons for an amino acid.
Term
What is accomplished during the process of translation
Definition
The synthesis of a polypeptide using the genetic information encoded in an mRNA molecule, involving a change of language from neucleotides to amino acids
Term
RNA molecules involved in Gene expression
Definition
  1. RNA
  2. Pre-mRNA
  3. tRNA
  4. rRNA
Term
RNA
Definition
Ribonucleic Acid
Term
Pre-mRNA
Definition
the RNA transcript produced initially during transcription in eukaryotes
Term
mRNA
Definition
messenger RNA; the processed RNA transcript molecules that will actually be translated
Term
rRNA
Definition
ribosomal RNA; RNA that forms the structure of the ribosome
Term
DNA amino acid coding
Definition

A-T

G-C

Term
RNA amino acid coding and translation between DNA and RNA
Definition

AUGC

 

A-U

T-A

G-C

C-G

Term
Frameshift Mutation
Definition
A mutation which replaces an entire codon in a DNA sequence
Term
Substitutional mutation
Definition
a mutation in which a single amino acid is replaced with another base
Term
Virus definition
Definition
  1. Obligate intracellular paracitic particles that infect cells
  2. nucleic acids with protein coats.
  3. Nucleic acids hold instructions for creating more viruses
  4. most have a well-defined host range
  5. not considered to be living things
Term
Reassortment
Definition
Process by which a new virus is formed, and during which mutations can occur, leading to the production of new viruses.
Term
Capsid
Definition
protein coat which encloses the nucleic acid of a virus particle
Term
How to bacterial and eukaryotic genes differ
Definition
Bacteria do not carry Introns, while Eukaryotes do
Term
What do Genes, Codons, enhancesrs, and promoters all have in common?
Definition
They are all defined by the sequence of nucleotides they contain
Term
Where does hydrogen bonding in nucleotides play a direct role?
Definition
  1. Transcription
  2. Translation
  3. the shapes of proteins
  4. codon-anticodon matching
Term
During Translation, what establishes the reading frame
Definition
The start codon
Term
What is the single most important step to regulate in the regulation of gene expression?
Definition

Transcription

 

Term

Most general, common theme of gene regulation exemplified by both bacteria and eukaryotes?

 

Definition
Proteins interact with DNA to regulate transcription
Term
Why do operons enable bacteria to turn multiple genes on or off simultaneously?
Definition
  1. Multiple genes are served by one promoter
  2. a single mRNA transcript from an operon can contain instructions for making multiple proteins
  3. a repressor protein bound at the operator can turn off all the operon's genes
Term

Multicellular organisms need gene regulation in order to....

 

Definition
  1. Grow
  2. build functional organs
  3. repair damaged tissues
  4. develop from embryo to adult
Term
How would you document that evolution is occuring in a population?
Definition
measure changes in genes or heritable traits over time
Term
Relationship between evolution and evolutionary Theory?
Definition
evloutionary theory is an explanatory framework for understanding observed patterns, processes, and products of evolution
Term
What is most generally favored by natural selection
Definition
Producing greater numbers of offspring
Term
How is viral gene expression unique?
Definition
they use the RNA of the host cell to create more DNA, violating the central dogma
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