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Produced by CD4+ (mostly) and CD8+ (small) T cells 1-2 h after activation by antigens.
IL-2 leads to IL-2R expression on activated T cells (positive feedback) and causes T cell growth stimulation |
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| Released by CD4+ T cells and Mast cells leading to B cell isotype switching to IgE (determines Th2 response) |
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Released by CD4+ T cells and Mast cells and leads to activation of Eosinophils
Remember, Fc receptors on Eosinophils recognize IgE that is bound to helminths (produced in response to IL-4 in Th2 response). |
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Produced by stromal cells of bone marrow and thymus
Stimulates the proliferation of the earliest lymphocyte precursors (were talking before B or T) |
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| Immune suppression, especially relevant in Th2 response, where it inhibit s macrophage activation by INF-y. |
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| Released by macrophages to stimulate T-cells. Release favors Th1 response (remember, IFN-y/IL-12 cross talk with macrophages and NK cells). |
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| Inhibit macrophage activation in Th2 response (also accomplished by IL-4 and IL-10) |
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| Secreted by CD4+ T cells to inhibit T-cell activation |
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