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Innate Immunity
Biology 200 Lecture Notes
11
Biology
Undergraduate 2
08/04/2011

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Term
How does the eye act as a passive barrier?
Definition
Blinking wipes tears across the eye. Tears contain the antibacterial enzyme lysozyme.
Term
How do the ears act as passive barriers?
Definition
Hairs and ear wax trap pathogens in the passageway of the external ear.
Term
How does the nose act as a passive barrier?
Definition
The nasal passages are lined with mucus secretions and hairs that trap pathogens.
Term
How does the digestive tract act as a passive barrier?
Definition
Pathogens are trapped in saliva and mucus, then swallowed. Most are destroyed by the low pH of the stomach.
Term
How do the airways act as a passive barrier?
Definition
Instead of reaching the lungs, most pathogens are trapped in mucus and swept up and out of the airway by the cilia.
Term
Treating a Wound
Definition
1) Bacteria and other pathogens enter wound.
2) Platelets from blood release blood-clotting proteins at wound site.
3) Neutrophils arrive, begin removing pathogens by phagocytosis.
4) Some newly arrived leukocytes mature into macrophages that phagocytize pathogens and secrete key cell-cell signals.
5) Mast cells at the site secrete factors that constrict blood vessel at the wound, and dilate blood vessels near the wound.
Term
What is an antigen?
Definition
Any disease-causing bad thing in your body that is not one of your own cells.
Term
What is an epitope?
Definition
Any small, recognizable shape on an antigen surface.
Term
What is the structure of an antibody?
Definition
Shorter light chains disulfide-bound to longer heavy chains. (T-like shape)
Term
Somatic Recombination
Definition
- Start with DNA containing full set of V, J, and C segments.
- One V segment joins with one J segment and the C segment by recombination.
- Translation results in a protein with a unique amino acid sequence.
Term
Components of the Immune System
Definition
Lymphocyte origin (bone marrow); lymphocyte maturation (bone marrow[B cells], thymus [T cells]); lymphocyte activation (spleen, lymph nodes); lymphocyte transport (lymphatic ducts, blood vessels).
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